(1999). The structure-based design of ATP-site directed protein kinase inhibitors. Curr Med Chem 6, 775 - 805.Toledo, L. M.; Lydon, N. B.; Elbaum, D. The structure-based design of ATP-site directed protein k...
ChemInform Abstract: The Structure‐Based Design of ATP‐Site Directed Protein Kinase Inhibitors The Structure-Based Design of ATP-Site Directed Protein Kinase Inhibitors. Curr. Med. Chem. 1999, 6, 775-805.Toledo, L. M.; Lydon, N. B.; ... LM Toledo,NB Lydon,D Elbaum - 《Cheminform》 ...
E. The superfamily of UvrA-related ATPases includes three more subunits of putative ATP-dependent nucleases. Protein Seq. Data Anal. 5, 43–45 (1992). CAS PubMed Google Scholar Berger, J. M., Gamblin, S. J., Harrison, S. C. & Wang, J. C. Structure and mechanism of DNA ...
(1989): Hypothetical structure of the ATP-binding site of (Na++K+)-ATPase. Gen. Physiol. Biophys. 8, 283--286Breier A, Turi Nagy L, Ziegelh6... A Breier,L Turi-Nagy,A Ziegelhffer,... - 《General Physiology & Biophysics》 被引量: 9发表: 1989年 Structure-based assignment of the ...
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We have crystallised and solved the X-ray structure of GlnK at 2.0 resolution. The asymmetric unit has two independent copies of the GlnK subunit and both pack around 3-fold axes to form trimers. The trimers have a barrel-like core with recognition loops (the T-loops) that protrude ...
Ⅰ. Structure: A description of all covalent bonds (mainly peptide bonds and disulfide bonds) linking amino acid residues in a polypeptide chain is itsprimary structure(The most important element of primary structure is the sequence of amino acid residues) ...
Interestingly, the spontaneous dimerisation of NBDs was also observed in absence of ATP molecules. The difference between simulations and cryo-EM structure might be partially explained by the use of non-native detergent in experiments7,11. Indeed, resolved cryo-EM structures of bMRP1 exhibited ...
29、 storage sites for starch, proteins, and oils; and chromoplasts, which contain pigments. The most important chromoplasts are chloroplasts-organelles that contain the chlorophyll used in photosynthesis. The internal structure of chloroplasts includes stacks of membranes called grana, which are emb...
The C-terminal putrescine moiety is introduced by the unusual termination module 13, the condensation domain directly catalyzes the assembly of putrescine into the peptidyl backbone, and other domains are essential for stabilizing the protein structure. Swapping of this module to another two nonribosomal...