SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining
In Mus musculus, the deletion of the Y chromosome region harboring Sry results in sex reversal (XYTdym1 female) and subfertility on a mixed genetic background5. When most copies of Rbmy repeats on the Y chromosome are deleted, the Sry gene is repressed during gonadal differentiation and sex...
Human MutationCameron FJ, Smith MJ, Warne GL and Sinclair AH (1998) Novel mutation in the Sry gene results in 46,XY gonadal dysgenesis. Hum Mut Suppl 1: S110–S111Cameron FJ, Smith MJ, Warne GL, Sinclair AH (1998) Novel mutation in the SRY gene results in 46,XY gonadal dysgene- ...
cabrerae. Examining the possible origin of SRY pseudogene and retroposons association, we propose that retroposons could have been involved in the mechanism of SRY gene amplification on the Y chromosome and in the transference of the Y-linked SRY copies to the X-chromosome heterochromatin....
This is the largest study to date that has investigated Y-chromosome deletions in men who were not ascertained on the basis of spermatogenic failure and reports that a deletion of some kind is present in 1 in 27 men. Article CAS PubMed PubMed Central Google Scholar Sato, Y. et al. Y...
. It's common for sex chromosomes to break down over time. "Acquisition of a gene that determines sex is the kiss of death for a chromosome, because other genes nearby on the Y evolve a a male-specific function, and these genes are kept together by suppressing exchange with the X."...
The SRY gene, located on p11.2 of the Y chromosome, has a sex-determining region and plays an essential role in the process of sex determination [2–4]. Mutations in the high mobility group (HMG) domain of the SRY gene affect binding to and bending of DNA or nuclear transport in ...
Sequence identity between the sperm whale SRY fragment and the homologous motif in a variety of other mammals was high, though generally higher with ungulates (similar to 88%) than with the human (85%), rabbit (80%), mouse (75%), or marsupial mouse (66%). When primers based on the ...
SRY and AZF gene variation in male infertility: a cytogenetic and molecular approach Aim The aim of this study was to identify the genetic effects of Y chromosome and azoospermia factor (AZF) gene variation in men with infertility and to e... O Ozdemir,E Gul,H Kilicarslan,... - 《Intern...
We found that microsatellites have strongly accumulated on the large W chromosome of L. reinhardti but not on the reduced-size W chromosome of T. auritus and are therefore important players of the W chromosome expansion. The present data highlight that the evolution of the sex chromosomes can ...