The role of spike-in standards in the normalization of RNA-seq In: Nettleton D, Datta S, editors. Statistical Analysis of Next Generation Sequence Data . Springer; 2014. p. 169–190.Risso D, Ngai J, Speed TP, Dudoit S. The role of spike-in standards in the normalization of RNA-seq....
Guided by gut sensory cues, humans and animals prefer nutritive sugars over non-caloric sweeteners, but how the gut steers such preferences remains unknown. In the intestine, neuropod cells synapse with vagal neurons to convey sugar stimuli to the brain
32. This family of proteins contains two motifs found in several transcription factors: a domain that is distantly related to the Pol II–associated domain of the elongation factor TFIIS, called
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This creates concern about whether the weather-normalization process is underestimating customer loads on realized peak days (e.g., in 2017) in the avoided cost data. As a check on robustness to this concern, we again compare with metered 2013 data for approximately 500 C&I customer loads in ...
2 Implement and troubleshoot SIP trunks in a multi-tenant environment a)Authentication b)Multi-VRF SIP trunks 3 Implement and troubleshoot SIP normalization and SDP normalization a)Normalization and transparency scripts (Lua) b)Cisco IOS-XE SIP profiles ...
factor (e.g. normal/tumor or two tissues), then global normalization methods should not be applied because the methods will remove the interesting biological variation (i.e. differentially expressed genes) and artificially induce differences between genes that were not differentially expressed. In the...
mRNA 3′ end processing involves specific endonucleolytic cleavage and the addition of a polyadenosine (poly(A)) tail onto the new 3′ end by the cleavage and polyadenylation factor (CPF in yeast and CPSF in human) (Kumar et al., 2019; Sun et al., 2020). Endonucleolytic cleavage ...
where λij represents the true expression value that underlies the observed UMI count Xij of gene i in cell j, and sj denotes the size normalization factor in cell j. The αij and βij are shape parameter and rate parameter respectively. Given the assumption that the shape parameter α is...
Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with the Nuclear Receptor Co-Repressor Complex 1 and 2 (NCoR1/2) and recruits it to key trophoblast genes. Genetic ablation of Erf or Tbl1x...