These mtDNA-encoded proteins have provided an invaluable alternative to nuclear gene sequences as a source for molecular phylogenetics, by both elucidating and confirming relationships among eukaryotes. However, only a small fraction of the mitochondrial proteome is encoded by the mitochondrion. Indeed, ...
2. New functions have been incorporated into the bacterial blueprint during mitochondrial evolution, while many ancestral traits have been lost. Importantly, in some cases, these losses occurred independently in different lineages of eukaryotes, resulting in a patchy distribution of the respective...
mediates the initial steps of the import of preproteins into the organelle, which are essential for mitochondrial biogenesis and, therefore, for eukaryotic cell viability . the tom complex is a multisubunit molecular machine with a dynamic structure. the biogenesis of tom is of special interest ...
Biogenesis of mitochondria: molecular mapping of the mitochondrial genome of yeast 来自 Semantic Scholar 喜欢 0 阅读量: 18 作者: AW Linnane,HB Lukins,PL Molloy,P Nagley,J Rytka,KS Sriprakash,MK Trembath 展开 摘要: We have developed a new procedure for the detailed molecular mapping ...
Data are representative of two independent experiments. Source data are provided as a Source Data file. Full size image Next, we used a neutralizing antibody that specifically disrupts LFA-1-ICAM-1/2 binding to evaluate the importance of this interaction for cytotoxic secretion. LFA-1 blockade ...
Source of the EST and number of independent sequences from various stages is indicated as are the unigene sequence match to the preliminary Pt genome 454 reads, the prediction by GeneMark and the closest homolog found among the predicted Pgt proteins. GO-annotations are also given according to ...
Sequence analysis of organelle genomes has revealed important aspects of plant cell evolution. The scope of this study was to develop an approach for de novo assembly of the carrot mitochondrial genome using next generation sequence data from total genom
exogenous DNA migration and frequent recombination of repeat sequences, its structure has undergone complex changes during evolution [12]. As an independent source of genetic information, the mitochondrial genome is of great significance for studies of species identification, development, and evolution [...
The major source of ATP is the mitochondria. VDAC1, as the ATP transporter,59 controls the cellular and extracellular ATP levels, and thereby, activation of P2X7R. The increased levels of P2X7R in DSS-induced colitis were suppressed by VBIT-12, supporting the involvement of VDAC1 in P2X7R...
Malic enzyme 1(ME1) is frequently overexpressed in cancers, and catalyzes the reversible oxidative decarboxylation of malate to pyruvate, yielding NADPH from NADP+, ME1 as a major cytoplasmic source of NADPH. In Synovial Sarcoma, the absence of ME1 shifts antioxidant system dependence and increases ...