The sodium-potassium pump controls the 550 intrinsic firing of the cerebellar purkinje neuron. PLoS ONE 7: e51169, 2012.Forrest MD, Wall MJ, Press DA, Feng J (2012) The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. PLoS One 7:e51169. CrossRef ...
the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell.
The figure shows the tunnel-like entry point to the binding sites of the sodium-potassium pump in the sodium-bound state. The three small sodium ions are bound inside the pump (violet spheres to the left), whereas there is not sufficient room for the larger potassium ions (green spheres to...
potassium (pəˈtæsɪəm) n (Elements & Compounds) a light silvery element of the alkali metal group that is highly reactive and rapidly oxidizes in air; occurs principally in carnallite and sylvite. It is used when alloyed with sodium as a cooling medium in nuclear reactors and...
1. The Na + -K + pump current was studied in smooth muscle cells from mesenteric resistance arteries of guinea-pigs by the use of the perforated patch-clamp technique in the presence of blockers for various ion channels and exchangers. 2. When the Na + concentration in the pipette solution...
当神经细胞处于休息状态时，细胞膜内外存在恆定的电位差，称为静止膜电位（resting membrane potential）。
1. When red cells loaded with (24)Na are incubated in balanced glucose salt solutions, the removal of external potassium reduces sodium efflux by about one third. Ouabain reduces the residual sodium efflux by about one half.2. The ouabain-sensitive efflux of sodium into potassium-free solutions...
Potassium Channel Inhibitor Block efflux of potassium ions through the cell membranes, resulting in a prolongation in action potentials. Satolol Amiodarone Amifampridine [82] Potassium-sparing Diuretics Act either by disrupting the exchange of sodium-potassium in the distal convoluted tubule or as an al...
3.Activetransport:Carrierprotein-mediatedmovementupthegradientA.Thisprocessdiffersfromfacilitateddiffusionintwocrucialaspects:Activetransportmaintainsthegradientsforpotassium,sodium,calcium,andotherionsacrossthecellmembrane.Alwaysmovessolutesupaconcentrationorelectrochemicalgradient;Activetransportcouplesthemovementofsubstancesagain...
Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood. In particular, the role of the intrinsic metal binding domains (MBDs) is enigm