Finnegan EJ,Matzke MA.The small RNA world. Journal of Cell Science . 2003Finnegan EJ, Matzke MA: The small RNA world. J Cell Sci 2003, 116:4689- 4693.EJ Finnegan,MA Matzke.The small RNA world. Journal of Cell Science . 2003Finnegan E. J., Matzke M.A. (2003). The small RNA ...
1986年,随着多种RNA核酶催化活性的发现,Walter Gilbert首次提出了“the RNA world”的假说 [1]。他设想了一个原始的、只含有RNA的世界:RNA分子催化自我复制,通过自我剪接产生具有功能活性的RNA分子,通过内含…
Micro RNA (MiRNA)-mediated plant gene expression reprogramming in the arbuscular mycorrhizal (AM) symbiosis. (a) SmallRNAome survey in different plant species identified target genes involved in several biological processes (Gu et al., 2010; Devers et al., 2011; Formey et al., 2014; Wu et...
A new paradigm of RNA-directed gene expression regulation has emerged recently, profound in scope but arresting in the apparent simplicity of its core mechanism. Cells express numerous small (∼22 nucleotide) RNAs that act as specificity determinants to direct destruction or translational repression ...
纵观对生命起源问题的探究历程,从最初的原始汤理论到“the RNA world”假说,可以发现,大多的研究都是基于现今发生的生命现象提出相应假说,并在实验室当中进行模拟实验推断假说的合理性,通过对如今各生命现象的不断研究发现新型证据的陆续填充来不断修正原有假说,但正应如此,绝大多数的实验往往只能在实验室条件进行,...
This issue of Nature Structural & Molecular Biology presents studies investigating RNA processing, including mechanisms of splicing, biogenesis of the splicing machinery, decoding of mRNA by the ribosome, and deadenylation of mRNA for degradation. We
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small nucleolar, small nuclear and vault RNAs),...
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small nu
MicroRNAs (miRNAs), non-coding RNA regulating gene expression, impact several cancer processes including drug resistance [20]. To delineate the role of miR- NAs in DLBCL response to treatment we performed: (i) A miRNA profiling, by small-RNA Seq, in serum samples of patients that led to ...
Small noncoding RNAs (sRNAs) with putative regulatory functions in gene expression have been identified in the enteropathogen Salmonella enterica serovar Typhimurium (S. Typhimurium). Two sRNAs are encoded by the genomic island GEI4417/4436 responsible f