Whereas in the earlier PD phases the dopaminergic neurons can store L-DOPA, as PD progresses and more dopaminergic neurons die this buffer function is lost, resulting in depleted brain DA storage. Eventually brain DA concentrations will then resemble blood DA ones, resulting in so-called “L-...
The conserved residue Tyr-168 is positioned 3.5 Å away from the modeled position of the sulfur atom of AcCoA and could serve as a general acid catalyst to protonate the incipient thiolate anion of CoA. AAA stands for an arylalkylamine substrate. The simplest mechanism for the transfer of ...
The molecules were integrated into three-terminal molecular transistor devices by direct covalent coupling of amine groups to carboxylic acid residues on the oxidized edges of graphene electrodes, which are generated during electroburning (Methods)18. The current Isd is measured on applying Vsd, and ...
The advent of modern antibiotics contributed enormously to the dramatic extension of human lifespan since their discovery by virtue of their lethal and selective action against pathogenic microbes. And yet despite our powerful arsenal of weapons against
Timber cladding has been used since historical times as a locally available, affordable weather protection option. Nowadays, interest in timber cladding is
The solvents listed come from a range of solvent types, classified according to their composition (aliphatic or aromatic hydrocarbon, oxygenated, halogenated), the presence of one or more functional groups (alcohol, ester, ether, ketone, carboxylic acid, amine, sulfoxide, sulfone, phosphoramide) or...
Two types of catalysts are used: amine (Dabco) and organometallic (Catalyst 12). The first one catalyzes crosslinking reactions, the second accelerates the reaction of isocyanate groups with hudroxyl groups. Tegostab surfactant is necessary to stabilize the structure of foams, facilitating the ...
The amine (1 equivalent) was dissolved in CH2Cl2. After cooling to 0 °C, the acid (1.1 equivalent), HOBt (1 equivalent), EDC (1.25 equivalent) and NEt3 (5 equivalent) were added successively to the solution. The reaction mixture was stirred at room temperature overnight. The solvent was...
The addition of HBr to 3-methyl-2-pentene is a stereoselective reaction. The simplest amine is CH3NH2, methylamine. (a) True (b) False -OH is a better leaving group than -Br. A) True B) False True or false? Structural isomers have the same molecular str...
RDX is also known ascyclonite,hexogen(particularly in Germany), andT4. Its chemical name iscyclotrimethylenetrinitramineis rather a mouthful and slightly boring. In pure form, RDX is a white, crystalline solid that is actually pretty stable to store at room temperature. You’d probably not gi...