Ploner C, Rainer J, Lobenwein S, Geley S, Kofler R. Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells. Apoptosis. 2009;14(6):821-828. 20C. Ploner, J. Rainer, S. Lobenwein, S. Geley, and R. Ko�er, "...
Nat Cell Biol 3: pp. 173-182Degterev A,Lugovskoy A,Cardone M,et al.Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-Xl.Nature Cell Biology. 2001Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-Xl. Degterev A...
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These regions are structurally heterogeneous, ubiquitous and found across all kingdoms of life. Despite the absence o
What is the molecular geometry of the PHCl2 molecule? What is the molecular geometry of the SO3 molecule? How do you determine the molecular shape of a molecule? Determine the molecular geometries of the following ions: 1. SCN^- A. linear B. tetrahedral C. bent D. trigonal pyrami...
At one extreme, the peptide epitope is recapitulated by a linear peptide epitope 1–4 amino acids long; there are four clinical-stage examples of small-molecule mimetics of these epitopes. PPIs that contain a single unit of secondary structure, such as an alpha helix, binding to a hydrophobic...
NH_3 j. CHCl_3 Nonpolar and Polar Molecules: To determine if a molecule is polar or nonpolar, you need to determine if there is a difference in electronegativity of the atoms and take into account the shape of the molecule. Remember,...
When the heart is stressed, mitochondria are frequently observed to change size and shape. The processes that mediate the fusion, fission and fragmentation of mitochondria comprise mitochondrial dynamics, and a competent mitochondrial dynamics system is essential for embryonic survival [1,2,3]. In gen...
The structure of a folded protein is commonly described in terms of its ‘native’ conformation discerned through X-ray crystallography. For an IDP, no single structure can be obtained. Instead, IDP structure is often described with reference to well-established homopolymer models16,17. However, ...
The structure of a folded protein is commonly described in terms of its ‘native’ conformation discerned through X-ray crystallography. For an IDP, no single structure can be obtained. Instead, IDP structure is often described with reference to well-established homopolymer models16,17. However, ...
The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. This article uses examples of successful discovery effort