Discusses the major illicit drugs in the black community. Cocaine; Crack; Heroin; Marijuana; PCP; Drug nicknames; Effects. INSET: Major illicit drugs in the black community..Ebony
These drugs bind to the ABCC8 and the closely related ABCC9 protein, and inhibit the KIR6 potassium channel. A polymorphism in the ABCC8 gene has been associated with insulin response in Mexican American subjects (23) and type II diabetes in French Canadians (24), but not in a ...
mRNA-based therapeutics—developing a new class of drugs. Nat. Rev. Drug Discov. 13, 759–780 (2014). Article CAS PubMed Google Scholar Xiao, Y. et al. Emerging mRNA technologies: delivery strategies and biomedical applications. Chem. Soc. Rev. 51, 3828–3845 (2022). Article CAS Pub...
It has been suggested that ABCG2 expression may be an important factor under hypoxic conditions [12], and multidrug transporters may significantly contribute to stem cell protection against drugs or xenobiotics [13]. There has been no detailed study reported as yet about the expression and ...
ATP-binding cassette ( ABC) transporters are a superfamily of integral membrane proteins located in several places in the human body, including the blood-brain barrier (BBB), and are involved in substrate translocation and tissue protection from harmful substances, including drugs of abuse. A growin...
In vitro systems that accurately model in vivo conditions in the gastrointestinal tract may aid the development of oral drugs with greater bioavailability. Here we show that the interaction profiles between drugs and intestinal drug transporters can be obtained by modulating transporter expression in inta...
In traditional Chinese medical science. thedrugsare also different from the West. because doctors have discovered the medicinal effects of thousand ofherbsover a long period of time. Before taking the medicine. the patient will have toboilit. Then there is thedistinctivemethod of preparation. ...
In bringing up the concept of GASPthe authoris making the point that [A] shareholders’ interests should beproperlyattended to(应适当关注股东的利益) [B] information protection should be given due attention(应给予信息保护问题应有的关注) [C] businesses should enhance their level of accountingsecurity...
as a vehicle and even as a home. The lenders feel happy when they chance to advance loans against any tangible property. They can grab the property if, for any ground whatsoever, the borrowers do not or can not pay back the loan amount within the agreed time. Of course, the lenders wa...
ABCG2 is an ATP-binding cassette (ABC) transporter whose function affects the pharmacokinetics of drugs and contributes to multidrug resistance of cancer cells. While its interaction with the endogenous substrate estrone-3-sulfate (E1S) has been elucidated at a structural level, the recognition and...