Based on this evidence SHP2 is considered a multifaceted target in cancer, spurring the notion that the development of direct inhibitors of SHP2 would provide the twofold benefit of tumor intrinsic and extrinsic inhibition. In this review, we will discuss the role of SHP2 in cancer and the ...
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Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive activati
(e) PTPN11 was classified as an SSD with very strong dependencies in a subset of breast cancer patients in TCGADEPMAP (blue bar, n = 7,021), (f) whereas no selectivity of PTPN11 essentiality was detected in DEPMAP (n = 810). For (A-F), the center horizontal line represents...
PTPN11 prostate stem cells Introduction The epidermal growth factor receptor (EGFR)2 has a crucial role in cell differentiation and proliferation. When first identified, it was considered to be the primary determinant of epithelial development, and the EGFR has been targeted by multiple antibodies in...
2. Tumor growth inhibition 3. Promotion of cell death 4. Reduction in inflammation 5. Inhibition of invasion and metastasis 6. Inhibition of the generation of vasculogenic mimicry 7. Others 8. Toxicity of RPS 9. Conclusions Data availability statement Funding Ethics statement CRediT authorship contr...
ARTICLE OPENTargeted Ptpn11 deletion in mice reveals the essential role ofSHP2 in osteoblast differentiation and skeletal homeostasisLijun Wang 1 , Huiliang Yang 1 , Jiahui Huang 1 , Shaopeng Pei 2 , Liyun Wang 2 , Jian Q. Feng 3 , Dian Jing 4 , Hu Zhao 4 , Henry M. Kronenberg 5 ,...
The role of PTKs in the development of human diseases has been a research focus for years. Recently, accu- mulating evidence indicates significant roles of some PTPs, such as Shp2, PTP1B, CDC25 and PRL3 in the development of some human diseases, cancer in particular2,3. Shp2 is the...
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.