The Role of Pax6 in the Nervous System during Development and in Adulthood: Master Control Regulator or Modular Function - Haubst, Favor, et al. - 2006 () Citation Context ...Paired Box gene 6 (PAX6) located on
During brain development, Pax6 is expressed in specific regions of the diencephalon including secretory cells of the subcommissural organ (SCO), a circumventricular organ at the forebrain–midbrain boundary that originates from the pretectal dorsal midline neuroepithelial cells beneath the posterior commi...
Chapouton, P., Gärtner, A. & Götz, M. The role of Pax6 in restricting cell migration between developing cortex and basal ganglia.Development126, 5569–5579 (1999). CASPubMedGoogle Scholar Tucker, K.L., Meyer, M. & Barde, Y.A. Neurotrophins are required for nerve growth during d...
S. (2004). Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J. Comp. Neurol. 479, 399-409. doi: 10.1002/cne.20317Nural HF, Mastick GS. 2004. Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J Comp Neurol 479:399-...
Pax6 Eye Neuroretina Limb Forebrain Dorsal root ganglia Rib Genital eminence Neural tube Cranial ganglia Smalleye 1. Introduction The Drosophila dachshund (dac) gene is involved in both eye and leg development as demonstrated in loss-of-function mutants in which the legs are drastically shortened an...
From day 20 onward, many forebrain progenitors expressing PAX6 (a cortical progenitor marker) and the proliferation marker MKI67 were observed in the cultures, whereas a small proportion of cells expressed neuronal differentiation markers such as ELAV4 and TUBB3. On day 23, cells were plated ...
The embryonic development of the vertebrate forebrain is guided by signals from three major patterning centers: a rostral patterning center that secretes fibroblast growth factors (FGFs), a caudodorsal center that secretes Wingless/Int proteins (WNTs) and bone morphogenetic proteins (BMPs), and a ...
PAX6 is a homeodomain transcription factor that acts in a highly dosage-sensitive manner to regulate the development and function of the eyes, nose, central nervous system, gut, and endocrine pancreas. Several individual microRNAs (miRNA) have been impli
Aberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, differentiation
Role of m6A in regulating neurogenesis Embryonic neurogenesis is coordinated between neural progenitor cell (NPC) proliferation and cell fate specification. NPCs differentiate into various neural and glial cell subtypes before migrating to their final destinations in the CNS [20,29]. In addition, long...