Molecular biology The role of Niemann-Pick C1-Like 1 (NPC1L1) protein in cholesterol transport and metabolic diseases WAKE FOREST UNIVERSITY Liqing YuPaul A. Dawson JiaLinNiemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein critical for intestinal absorption of dietary and ...
2005), but this can as well be explained by a role of NPC1L1 in forming of the protein complex necessary for clathrin-mediated endocytosis (Wang and Song 2012), thereby allowing access of ezetimibe to its primary molecular target putatively being different from NPC1L1. In contrast, a direct...
Even though the role of NPC1L1 is still debatable, one can theorize that an increase in NPC1L1 could aide in enhanced sterol movement (from LDL or HDL) across trophoblasts (71). SCP-2/x and ABCA2 (14, 15) were also expressed by the placenta, and as in other tissues, expression ...
DTP cells emerge in tumours that initially respond to systemic anticancer therapies and might not be involved in disease recurrence following local therapies such as surgery. Incomplete responses to systemic therapies might reflect the coexistence of several distinct populations of resistant cancer cells, ...
mTORC1 signalling has wide-ranging consequences for the growth and homeostasis of key tissues and organs, and its dysregulated activity promotes cancer, type 2 diabetes, neurodegeneration and other age-related disorders. How mTORC1 integrates numerous upstream cues and translates them into specific ...
Research over the past decade has improved our understanding of the biological roles of DTP cells in cancer, although clinical knowledge of the role of these cells in treatment resistance remains limited. Nonetheless, targeting this population is anticipated to provide new treatment opportunities. In ...
In contrast to the canoncical translational suppressive role of microRNAs, miR-122's interaction with the HCV genome is crucial for viral replication, translation and genome stability (Roberts et al., 2011; Li et al., 2013; Sedano and Sarnow, 2014; Masaki et al., 2015). Instead of ...
The role of zinc finger proteins in malignant tumors Jia Zhao, Doudou Wen, Shubing Zhang, Hao Jiang, Xiaotang Di e23157 First Published: 24 August 2023 The expression of Zinc finger proteins (ZNFs) is dysregulated in different tumor types, highlighting their roles as oncogenic and tumor ...
Role of aquaporins in oral cancer. J Cancer Res Ther. 2017;13:137–8. Article CAS PubMed Google Scholar Kaushik R, Goel A, Rout PK. Gene expression analysis of Aquaporin genes in ruminants during growth phase in response to heat stress. Int J Biol Macromol. 2024;281:136262. Article ...
In this chapter, we summarize the latest advances in the critical role of the sterol efflux transporters ABCG5/G8 in regulating hepatic secretion of biliary cholesterol, intestinal absorption of cholesterol and plant sterols, the classical reverse cholesterol transport, and the newly established trans...