Tumours co-opt myeloid cells to promote cancer growth. This process occurs not only within the local tumour microenvironment but also in various distant body compartments. Myeloid cells can favour or hinder each step of the metastatic cascade. Myeloid cells have a central, yet still largely unexplo...
Tumours co-opt myeloid cells to promote cancer growth. This process occurs not only within the local tumour microenvironment but also in various distant body compartments. Myeloid cells can favour or hinder each step of the metastatic cascade. Myeloid cells have a central, yet still largely unexplo...
The role of myeloid cells in the promotion of tumour angiogenesis. The use of various transgenic mouse models and analysis of human tumour biopsies has shown that bone marrow-derived myeloid cells, such as macrophages, neu... Craig,Murdoch,Munitta,... - 《Nature Reviews Cancer》 被引量: ...
MDSCs are immature myeloid immune cells, which accumulate in models of liver cancer to reduce effector immune cell activity, contribute to immune escape and treatment resistance. The accumulation of MDSCs suppresses the role of CTL and the killing effects of NK cells, induces the accumulation of ...
J. The role of myeloid cells in cancer therapies. Nat. Rev. Cancer 16, 447–462 (2016). Article CAS PubMed Google Scholar Schmid, M. C. & Varner, J. A. Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J. Oncol. 2010, 201026 (...
myeloid-derived suppressor cellsprogressionprognosistherapyGastrointestinal(GI)cancer encompasses a range ofmalignancies that originate in the digestive system,which together represent the most common form of cancer diagnosed worldwide.However,despite numerous advances in both diagnostics and treatment,the ...
Role of inflammatory cells during cancer progression How do cancer cells avoid destruction by the immune system? It is currently accepted that anaberrant innate and adaptive immune responsecontributestotumorigenesisbyselecting aggressive clones, inducing immunosuppression, and stimulating cancer cell proliferatio...
A1.02Important role of microrna-146A in inflammatory arthritis by controlling local bone destruction Background MicroRNA (MiR-) 146a is a key regulator of the innate immune response and has also been shown to suppress cancer development in myeloid cells., Although in late stages of arthritis elev...
Current cancer immunotherapies are primarily predicated on αβ T cells, with a stringent dependence on MHC-mediated presentation of tumour-enriched peptides or unique neoantigens that can limit their efficacy and applicability in various contexts. After
Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms Article Open access 27 May 2020 References Hayday, A. C. et al. Structure, organization, and somatic rearrangement of T cell gamma genes. Cell 40, 259–269 (1985). Article CAS PubMed Google Sc...