Lysosomes are the major degradative compartments within eukaryotic cells.Besides their role in the degradation and recycling of intra-and extracellular molecules,they further mediate important biological processes,such as immune signaling and perpetuation of nutrientand energy homeostasis.Denise BaltaFriederike ...
Moreover, lysosomes play an important role in autophagy. In mammalian cells, autophagy stimulation signals such as starvation can activate ULK complex (ULK1/2, FIP200, Atg13), which marks the initiation of formation of the phagophore. The recruitment of PI3K complex (VPS34, VPS15, Beclin1 an...
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention. Over the past decades, we largely focused on how lysosome influences apoptosis ...
Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner. Glycobiology 29, 151–162 (2019). CAS PubMed Google Scholar Chen, Y. J. et al. Galectin-3 enhances avian H5N1 influenza A virus-induced ...
& Amano, A. Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol. Biol. Cell 21, 1001–1010 (2010). CAS PubMed PubMed Central Google Scholar Rubinsztein, D. C...
In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms. In this review, we discuss the role of ...
and to hydrolyze the protein component of the lipoprotein in lysosomes, their defective lysosomal hydrolysis of the cholesteryl ester component of the lipoprotein led to the accumulation within the cell of unhydrolyzed cholesteryl esters, the fatty acid distribution of which resembled that of plasma lip...
The chelatable iron pool in living cells: a methodically defined quantity. Biol. Chem. 383, 489–502 (2002). Article CAS PubMed Google Scholar Kurz, T., Eaton, J.W. & Brunk, U.T. The role of lysosomes in iron metabolism and recycling. Int. J. Biochem. Cell Biol. 43, 1686–...
Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the ph