A 14-year-old male patient presented in diabetic ketoacidosis (DKA) and was diagnosed with presumed autoantibody-negative type 1 diabetes (T1D) as well as myeloid neoplasm with platelet-derived growth factor receptor beta (PDGFRB) rearrangement. After starting exogenous insulin and imatinib, he ...
In this Review, we describe key accomplishments leading to and building on this momentous occasion in medical history, including advancements in our understanding of the role of insulin in diabetes pathophysiology, the molecular characterization of insulin and the clinical use of insulin. Achievements ...
(1983) Introduction: The role of insulin resistance in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. The American Journal of Medicine 74 , 1-2 Online publication date: 1-Jan-1983. /Reaven GM (1983) Introduction: the role of insulin resistance in the pathogenesis and...
Diabetes mellitus (DM) is a chronic disease that affects approximately 425 million people worldwide, and research shows that this number will increase by 25% in 2030 and by 51% in 2045 [1]. DM is characterized by long-standing hyperglycemia due to defective insulin secretion, impairment of t...
Hyperglycemia is a common and challenging condition in hospitalized patients both with and without a history of diabetes. Managing hyperglycemia effectivel
In this regard, the mechanism of action of the thiazolidinediones is discussed and other adipocyte proteins are proposed as alternative targets for the development of antidiabetic therapeutics. Keywords: obesity; insulin resistance; type 2 diabetes; adipocyte; adipocytokines; adipogenic transcription factors...
Before the discovery of insulin (胰岛素),diabetes was a death sentence.(1)___ But why do some people need insulin and how does it work? Diabetes has been recognized as a disease since ancient times,and as early as 1775 physician Matthew Dobson detected the presence of sugar in the urine...
The prevailing type of diabetes in Caucasian children and adolescents is type l. Insulin resistance resulting from decreased physical activity and obesity may account for the rising incidence of type l and type 2 diabetes mellitus in this group. To estimate the role of insulin secretion and insulin...
Nowadays, there is a great need to determine a recommendation for the possible role of nutraceuticals in patients with statin-associated adverse effects. However, it is simultaneously critical to emphasize that nutraceuticals, both in patients with good adherence to statin therapy as well as with ...
to the risk of Type 2 diabetes(糖尿病), because more insulin(胰岛素) to absorb the sugar.“So what you’re doing is that yo the system harder,” Swithers says.1. What can we learn from Katie page's study? A. Females enjoying diet drinks consume more food. B. Artificial sweeteners ...