Aurora-A inhibitorsCancer stem cellsAurora kinase A (Aurora-A), a member of the Aurora family of serine/threonine kinases, plays a critical role in multiple steps of mitotic progression, including microtubule stability during the G1 phase of the cell cycle, chromosome alignment and segregation, ...
AURKA is predominantly recognized as a mitotic kinase, however, recent findings have uncovered an equally important role of interphasic AURKA in normal cells. In contrast, in cancer tissues, AURKA is overexpressed in a cell-cycle-independent manner and is mislocalized in the cytoplasm and/or nucle...
1a), cells were classified using five reference datasets (Fig. 1c). This yielded seven major cell types, comprised of various types of immune cells: T-cells, NK-cells, B-cells, myeloid cells, and plasmacytoid dendritic cells, followed by erythroid cells and stem cells, which were supported...
Although the immune tumour microenvironment (TME) serves as a source of therapeutic targets, it is also considered a friend or foe to tumour-directed therapies. This is readily illustrated by the importance of T cells in triple-negative breast cancer (TNBC), culminating in the advent of immune...
Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas: an accelerated growth factor in glioblastomas. CXCL12, an alpha-chemokine that binds to G-protein-coupled CXCR4, plays an important and unique role in the regulation of stem/progenitor cell trafficking.....
NK cells are a type of innate immune cells that is uniquely responsible for killing and removing diseased cells such as cancer cells. Allogene Therapeutics Launched April 2018, Allogene Therapeutics was formed by two former Kite Pharma executives and raised $300 million in investor funds to ...
Take a break from the toils of the SOTF ACT and relax in the tranquility of another roleplay. You decide what sort of roleplays appear here, be they AUs or something entirely different. You're only limited by your own imagination. ...
Future efforts should be put into the investigation of the normal developmental roles of p53 and compare them to those in cancer cells. Systematic analyses show that p53-regulated genes in ES cells are playing a role in breast cancer and prostate cancer, suggesting that the role of p53 in ES...
Keywords: autophagy; cancer; cancer stem-cells; autophagy modulators 1. Introduction Autophagy is a physiological cellular process for the degradation and elimination of misfolded proteins and damaged organelles that functions in adaptation to starvation, development, cell death, and tumor suppression [1,...
This perceived value and switching barriers essentially stem from the role of the potential factor expected benefits, with both product quality and supplier reputation only indirectly influencing users’ willingness-to-pay through expected benefits [12]. This conclusion, in turn, appears to evolve and...