(1996). The role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. Adv. Dev. Biol. 4, 27- 82.Rushlow, C. and Roth, S. (1996). The role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. Adv. Dev. Biol. 4, 27-82....
Interestingly, we find that induction of TkvCA results in elevated expression of vein, which further activates Epidermal Growth Factor Receptor (EGFR) signaling in CySCs to promote their proliferation and compete GSCs out of the niche. Our findings elucidate the important role of Dpp signaling in ...
The overwhelming increase in the prevalence of overweight and obesity in recent years represents one of the greatest threats to the health of the developed world. Among current treatments, however, gastrointestinal (GI) surgery remains the only approach
Thus, it is critical that the role of NLRP1 in each of these disease processes be robustly defined. In this review, we summarize the current research landscape to provide a better understanding of the mechanisms associated with NLRP1 function and dysfunction in human disease pathobiology. We ...
Early works on p53 have elucidated its canonical function in response to DNA damage. Specifically, in the presence of mild stress or damage signal, p53 blocks cell cycle pro- gression and activates DNA repair machinery to promote cell survival and maintain genome integrity. However, when the ...
The epidemic of type 2 diabetes (T2DM) is a public health problem that threatens to spiral out of control in the twenty-first century. Early intervention can greatly mitigate the serious socioeconomic impact of the disease, driven largely by disabling mi
Loss of function studies in mESCs, chick and Xenopus embryos also suggest a role for instructive signaling by FGF in neural induction. For example, inhibition of FGF receptors or Erk1/2 by exposure to pharmacological inhibitors eliminated differentiation of mESCs into neurons [22] and resulted in...
Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC ...
A. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol. Rev. 57, 387–395 (2005). Article CAS PubMed Google Scholar Catterall, W. A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26, ...
Evidence for increased gene expression of DPP8 and DPP9 in tubulointerstitium was found to be associated with the decline of kidney function in chronic kidney disease (CKD) patients, which was observed in the Nephroseq human database. To examine the role of DPP8 and DPP9 in the ...