ribotoxic stress responseZAK-alphapyroptosisapoptosisinflammationp38JNKSolar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cell death, and epidermal thickening, all of which have traditionally been associated ...
The ribotoxic stress response drives UV-mediated cell death Cell, 187 (2024), pp. 3652-3670.e40, 10.1016/j.cell.2024.05.018 View PDFView articleView in ScopusGoogle Scholar 30 L. Wan, S. Juszkiewicz, D. Blears, P.K. Bajpe, Z. Han, P. Faull, R. Mitter, A. Stewart, A.P. Snijd...
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response 核糖体停滞是核毒性应激反应的代谢调节信号 相关领域 核糖体 安普克 mTORC1型 翻译(生物学) 细胞生物学 生物 PI3K/AKT/mTOR通路 信号转导 严格的回应 P70-S6激酶1 综合应力响应 p38丝裂原活化蛋白激酶 激酶 蛋白激酶A...
p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellu
through interaction with the peptidyl transferase at the 60S ribosomal subunit (Rocha et al.2005). The binding of DON to the ribosome rapidly activates MAPK signaling pathways and induces caspase-mediated apoptosis in a process known as the “ribotoxic stress response” (Pestka2010b; Rocha et al...
Stress response, chemotaxis and motility. As a recalcitrant carbon source, 17β-estradiol brings potential stress to bacterial growth in many aspects, although it can be eventually mineralized as a carbon and energy source. These growth stresses can be defined as an overload of some ...
Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 274, 13985–13992. https://doi.org/10.1074/jbc.274.20.13985 (1999). Article CAS PubMed Google Scholar Li, M. ...
As the role of RNA modification in gene expression regulation and human diseases, the “epitranscriptome” has been shown to be an important player in regulating many physiological and pathological processes. Meanwhile, the phenomenon of cancer drug resi
Consequently, the term “nucleolar stress” was traditionally used to refer to “ribotoxic stress” or “ribosome biogenesis stress.” Nucleolar stress has just emerged as a novel concept, and it is now referred to as diverse cellular insults that induce abnormalities in nucleolar structure and ...
In a similar manner activation of autophagy, which recently has been found as a novel nucleolar stress-induced response,85 can either be beneficial or toxic for the cells depending on the context.95 Pointing in that direction, intranasal administration of Wnt3a was recently shown to counteract ...