1.any of numerous organic molecules constituting a large portion of the mass of every life form, composed of 20 or more amino acids linked in one or more long chains, the final shape and other properties of each protein being determined by the side chains of the amino acids and their chem...
The structure of coronavirus comprises four major parts: spike protein (S), nucleocapsid protein (N), membrane protein (M), and envelope protein (E). The spike protein is discovered from the outer portion of the virus with 150 kDa molecular weight [11]. The spike protein of SARS-CoV-2 ...
Caloric restriction (CR), defined as lessening caloric intake without depriving essential nutrients4, results in changes in molecular processes that have been associated with aging, including DNA methylation (DNAm)5,6,7, and is established to increase healthy lifespan in multiple species8,9. Here...
b. gambiense (group 1) resistance to TLF-1 correlated with the loss of the haptoglobin/hemoglobin receptor (HpHbR) expression, the protein responsible for high affinity binding and uptake of TLF-1. In the course of these studies we also examined TLF-1 resistant T. b. brucei cell lines, ...
The slope (−kobs, observed rate) of each line was then calculated for the linear portion of the curve and the nonlinear outliers, as determined by GraphPad automatic outlier elimination, were excluded. A statistical test was applied at each inhibitor concentration to evaluate if kobs was ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus responsible for the current coronavirus disease 2019 (COVID-19) pandemic, has infected over 3.5 million people all over the world since the first case was reported from Wuhan, Ch
The recent outbreak of the Coronavirus pandemic resulted in a successful vaccination program launched by the World Health Organization. However, a large population is still unvaccinated, leading to the emergence of mutated strains like alpha, beta, delta
detected in patients withJAK2/MPLunmutated ET and PMF61,62. These are highly heterogeneousindels, all clustering in exon 9 that encodes for the C-terminus portion of the protein. There are two prevalent (>80% of allCALRvariants) mutation types, type 1 (a 52-bp deletion; p.L367fs*46) ...
A layer of the hippocampus that contains a portion of the apical dendrites of CA1 pyramidal cells and the axons (Schaffer collaterals) of the CA3 pyramidal cells that form synapses onto the CA1 dendrites. Oligaemia A mild or moderate reduction in blood flow to the brain. Familial hemiplegic...
That functions as a component of a number of proteins, including enzymes and hemoglobin, the latter being important for the transport of oxygen to tissues throughout the body for metabolism [110]. A hundred grams of the fruit powder of G. tenax, G. flavescence, and G. villosa can fulfil...