Some of these signaling pathways have direct osteoinductive effects, which help the bone repair process. Understanding the crosstalk between osteoinductive molecular pathways in bone formation and bone regeneration may pave the way for novel treatment options and the development of cell-based therapeutic...
Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging wit
However, a series of challenges remains to be addressed before mRNA can be established as a general therapeutic modality with broad relevance to both rare and common diseases. An array of new technologies is being developed to surmount these challenges, including approaches to optimize mRNA cargos,...
Define bone formation. bone formation synonyms, bone formation pronunciation, bone formation translation, English dictionary definition of bone formation. n. 1. a. The dense, semirigid, porous, calcified connective tissue forming the major portion of the
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxy... SIMAO,MS A.,YADAV,... - 《Brazilian Journal of Medical & Biological Research》 被引量: 23发表: 2010年 Bio-compatible ceramics as mimetic ma...
It was found that ultrasound at 0.1 W/cm2 (SATA), pulsed 1:4, 3 MHz, 5 min, significantly stimulates bone formation (i.e., the synthesis of collagen and NCP) (p < 0.001 and p < 0.01). However, pulsed ultrasound at higher doses (1.0-2.0 W/cm2 (SATA), pulsed 1:4, 3 MHz,...
The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. The approximate equality of whole-body rates of formation and resorption over a wide range, a phenomenon frequently but inaccurately referred to as coup...
This study aimed to investigate the correlation between bone mineral density (BMD) and the turnover rate [√(MoMf 2 +MoMr 2 ), multiple of median formation (MoMf) was calculated as bone-specific alkaline phosphatase (BAP) value/18.6 and multiple of median resorption (MoMr) as tartrate-resis...
repair is not a simple process of bone formation and bone resorption, but a close interaction of multiple systems, including the skeletal system and the immune system, which is regulated by cytokines, stress stimulation and inflammatory response.15Although bone transplantation, bone transport technology...
Background and Objectives: To establish a method to induce goat bone marrow derived stromal cells (BMSCs) differentiate to osteoblast in vitro, and to exam the bone formation related gene expression changes in mRNA level after a certain inducing time. Methods: By using whole bone marrow culture...