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The concentration of testosterone was found to be higher in serum from female than from male trout indicating that testosterone is unlikely to be the principal androgen in trout. High concentrations of 11-oxotestosterone in male and barely detectable levels in female fish support the hypothesis that...
The first two principal components used. The underlying data is the RPKM read depth for DMR genomic windows. (A) Mild (distal) hypospadias, (B) Moderate hypospadias (moderate), (C) Severe (proximal) hypospadias, and (D) Combined mild, moderate, and severe hypospadias. Full size image...
This article is part of a Special Issue "Hormones & Neurotrauma".Age-related loss of sex steroid hormones is a established risk factor for the development ... RS Vest,CJ Pike - 《Hormones & Behavior》 被引量: 172发表: 2013年 Neuroendocrine consequences of androgen excess in female rodents ...
non-basal-like tumors almost solely consisted of the MC1 and MC2 subtypes (Supplementary Fig.S7c), which appeared only in the HER2-low group and not in the HER2-0 group (Table2) and were both exclusively immunomodulator negative19. In the principal component analysis of all genes, HER2-low...
The challenge with bone biopsies of metastatic disease is, the principal challenge once you’ve got a decent yield of sample is that we use decalcifying chemicals to soften the bone to make sections. And that’s very hard to bypass in a system. But it’s actually that step after fixation...
. Activity of the EZH2 inhibitor CPI-1205 in combination with the antiandrogen enzalutamide (Xtandi) is being tested in Phase I/II trials as second-line treatment of metastatic castration-resistant prostate cancer patients (NCT03480646), and showing excellent tolerance and considerable anticancer ...
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Since the androgen receptor (AR) is required for PCa pathogenesis, androgen deprivation therapy has been the principal treatment for aggressive PCa; however, despite the high initial response rates, these tumors ultimately develop resistance, i.e., castration-resistant PCa (CRPC) [79]. Recent ...