Insulin, a primary metabolic hormone, plays a dominant role in the regulation of food intake. An increase in the level of circulating insulin produced by its prandial release from endogenous stores is associated with the state of satiety. On the other hand, an increase in the insulin level pro...
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GPs often have to rely heavily on their practice nurses to undertake a large proportion of the diabetes work for them: A practice nurse competencies questionnaire for the 10 pilot practices in Central Norfolk was completed in 2002. This showed that lack of...
aThe primary objective of this research is to determine whether there are significantly different outcomes for children with newly diagnosed type 1 diabetes who are clinically well, when they are either admitted to hospital or managed at home for initiation of insulin treatment and education of child...
Several cellular signaling pathways, including insulin/IGF signaling, are known to be activated in hepatocellular carcinoma (HCC). Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be
A critical step in ovarian biology is the transition of the developmentally arrested primordial follicle to the growing primary follicle. The current study utilizes a rat ovarian organ culture system to investigate the role of insulin and insulin-like growth factor-1 (IGF-1) in this process. Four...
The primary aim of the study is to evaluate the comparative effects of consumption of dairy products containing A2 beta-casein versus conventional dairy (i.e. containing both A1 and A2 beta-casein) on symptoms of psychological distress in women with low mood. Methods ‘The Moo’D Study’ is...
Introduction The increasing prevalence of diabetes in the UK and the management of patients with type 2 diabetes in primary care are high on everyone's agenda. This article examines the barriers and resistance to starting insulin in primary care and some local strategies for overcoming these barrier...
Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ (PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances in protein structure determination and drug development have allowed for generati
Our current food system relies on unsustainable practices, which often fail to provide healthy diets to a growing population. Therefore, there is an urgent demand for new sustainable nutrition sources and processes. Microorganisms have gained attention a