The pyruvate dehydrogenase complex (PDC) catalyzes the irreversible decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in any of the genes encoding its several subunits. The resulting phenotype, though very heterogeneous, mainly affects the central nervous system. ...
Y.; MORZHAKOVA, A. A.; GULEVICH, A. Y.; DEBABOV, V. G. Manipulating pyruvate to acetyl-CoA conversion in Escherichia coli for anaerobic succinate biosynthesis from glucose with the yield close to the stoichiometric maximum. Journal of Biotechnology, v. 214, p. 33-42, 2015....
In this study, we investigate the outcomes of dysregulated AT-1 activity on intracellular acetyl-CoA homeostasis. Changes in the intracellular acetyl-CoA flux caused by hypoactive or hyperactive AT-1 could conceivably influence phenotypes beyond the secretory pathway; in particular the metabolic effects...
Both collagen and glutamine-derived proline synthesis in CAFs are epigenetically upregulated by increased pyruvate dehydrogenase-derived acetyl-CoA levels. PYCR1 is a cancer cell vulnerability and potential target for therapy; therefore, our work provides evidence that targeting PYCR1 may have the ...
ACSL4 induces fatty acid activation and β-oxidation to promote cell survival Triglyceride catabolism releases fatty acids, which are further broken down via β-oxidation mainly in mitochondria and peroxisomes to generate acetyl-CoA for mitochondrial ATP production. Following glucose starvation, ACSL4-hig...
(NADPH), hydroxymethylglutaryl-CoA reductase, mevalonate kinase, phosphomevalonate kinase, diphosphomevalonate decarboxylase, and isopentenyl-diphosphate delta-isomerase. We also observed enriched KO modules in the bladder genomes related to acetyl-CoA, which is the precursor for the MEV pathway of ...
Autotrophic acetogens can use the reductive acetyl-CoA pathway for the production of acetic acid and ethanol as well as some other minor metabolites such as butanol, lactate, butyrate, hexanoate, and 2,3-butanediol using CO2 and CO as the carbon sources (1). Some acetogens are human gut ba...
In the current study, transcriptomic and metabolomic analyses were creatively adopted to directly investigate the responses in the livers of growing pigs fed NSPs enriched diets. Acetyl-CoA acyltransferase including two isoformsACAA1andACAA2, which catalyzes the last step of the fatty acid beta-oxidati...
(PDH). The first component enzyme of the pyruvate dehydrogenase complex; it converts pyruvate into acetyl-CoA, which enters the tricarboxylic acid (TCA) cycle for cellular respiration. Glycolytic flux The rate at which glucose and its metabolites proceed through the glycolytic pathway. Flux analysis...
The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathw...