Unexpectedly, metabolic profiling suggested that both compounds also inhibit dihydroorotate dehydrogense (DHODH), which is required for pyrimidine synthesis and is a validated drug target in its own right. Expression of yeast DHODH, which bypasses the need for the parasite DHODH, increased parasite ...
The CrO9 compounds are more active than CrO5, but their preparation in the finely divided state is difficult because of the high exothermicity of the oxidation stage, which results in the decomposition of the oxides CrO9 and CrO5 followed by the crystallization and sintering of the decomposition...
Besides maintaining the mechanical stability of the heart and enabling the electrical coupling between ventricular cardiomyocytes, desmosomes may also play a crucial role in intracellular signal transduction and gene expression [2]. For instance, when the desmo- somal assembly is disrupted by genetically...
Changes caused by thermal stress have been observed in the proteome of organisms from other phyla, such as the benthic foraminifera Amphistegina gibbosa [43]. Not only the transcriptome and the proteome, but also the metabolome of both partners of the symbiosis is affected by thermal stress. ...
Direct DNA damage caused by ionising radiation occurs in clusters within the DNA structure (which is more resistant to a cell's own DNA repair mechanism) [24]. Secondly, ionizing radiation causes the radiolysis of water (70% of a cell's makeup) and stimulates nitrogen oxide synthetase to ...