After consumption, FLX is metabolized and then excreted from the human body primarily through the urine with up to 11% of the administered FLX dose being excreted as the unchanged parent compound4–6. The excreted FLX and its potent metabolite, norfluoxetine, which also acts at SERT, then ...
These results were validated in a large (n = 123) cohort of prospectively collected human colorectal carcinomas. We found that, while FRA1 was mainly localized in the nucleus of cancer cells, its acetylated form was mainly present in the cytoplasm, i.e., indicative of low K116Ac ...
Among the human genome, p53 is one of the first tumor suppressor genes to be discovered. It has a wide range of functions covering cell cycle control, apoptosis, genome integrity maintenance, metabolism, fertility, cellular reprogramming and autophagy. Although different possible underlying mechanisms ...
Capece D, Fischietti M, Verzella D, Gaggiano A, Cicciarelli G, Tessitore A, Zazzeroni F, Alesse E: The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages. Biomed Res Int. 2013, 2013: 187204- PubMed Central PubMed Google Scholar Prieto...
Karel Allegaert8, Paul D imitri9, Frantisek S taud10, Elke Smits11, Marina Kleanthous12, Sergio G iannattasio13, Nunzio Denora14, Catherine Tuleu4, Donato B onifazi2 1Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Valen‑ zano (BA), ...
Mukutmoni-Norris M, Hubbard NE, Erickson KL (2000) Modulation of murine mammary tumor vasculature by dietary n-3 fatty acids in fish oil. Cancer Lett 150(1):101–109 ArticleCASPubMedGoogle Scholar Anderson RE, Penn JS (2004) Environmental light and heredity are associated with adaptive chang...
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Mukutmoni-Norris M, Hubbard NE, Erickson KL (2000) Modulation of murine mammary tumor vasculature by dietary n-3 fatty acids in fish oil. Cancer Lett 150(1):101–109 ArticleCASPubMedGoogle Scholar Anderson RE, Penn JS (2004) Environmental light and heredity are associated with adaptive chang...
As members of the nuclear receptor superfamily, both ER subtypes have three main functional domains: the N-terminal domain with activation function 1 (AF-1) that regulates target gene transcription independent of ligand activation, the DNA-binding domain (DBD) that facilitates binding to specific ...
As members of the nuclear receptor superfamily, both ER subtypes have three main functional domains: the N-terminal domain with activation function 1 (AF-1) that regulates target gene transcription independent of ligand activation, the DNA-binding domain (DBD) that facilitates binding to specific ...