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To capture cellular heterogeneity in the cerebral cortex, we performed single-cell (sc) ATAC-seq and RNA-seq at the same time in the same individual cells using the Multiome approach (Chromium platform − 10x Genomics)8. We generated pooled libraries from three E14.5 and P2 cortices of bo...
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suffer from replicative stress, targeting DDR processes could indu...
the universal CAR-T cells are designed using BBIR CAR or SUPRA CAR. The tumour-specific scFv extracellular structural domain used in previous generations of CAR-T cells is replaced in the universal CAR-T cells with an adapter-specific recognition structural domain that binds to an ...
Convergence in certain cases: The Nelder–Mead algorithm can converge quickly for low-dimensional problems with smooth, convex objective functions. Robustness: It is relatively robust against noisy or imperfect function evaluations. 2.2.2. Disadvantages of the Nelder–Mead Algorithm Some disadvantages of...
N = 117 cells for (L) and (M). Further examination of the arrest trajectory revealed that cells do not exit the cell cycle into a single, static arrest state awaiting cell cycle re-entry. Instead, cells progressed further along this trajectory with time (Figure 1D) accompanied by a ...
8. Each surface has the same structure and interface that mechanically connects to other cells, such that there is no need to distinguish directions during its operation. OSR performs operations such as insertion and rotation via connector plugs, while completing the power supply and communication ...
anepememan, for instance, can be understood as a solution to the question of what to do in a certain situation. The decisions this obligation prescribes maximizes the agent’s perceived value of his/her action. But agents sometimes treat the ascribed value as an objective feature of the ...
It is commonly known that HIV infection in chimpanzees does not progress to the level of medical complexity that is seen in human AIDS [41]. In chimpanzees the virus lives in a benign relationship within the immune system whereas in humans it infects and destroys helper T-cells. Functional ...
objective. For imaging at an index ofn = 1.45, the immersion chamber was filled with a fused silica matching liquid (50350, Cargille). Type A immersion oil (16482, Cargille) was used for measurements atn = 1.51. The liquids were chosen such that the fluorescent beads did not ...