irregularis transcripts (Fig. 3a, ii) showed distinct patterns of messenger RNA capture and expression between the two species, indicating the successful spatially resolved capture of transcriptomes during symbiosis. Fig. 2: Spatial transcriptomics enables simultaneous capture of M. truncatula and R. ...
Cancer immunotherapy has rapidly transformed cancer treatment, yet resistance remains a significant hurdle, limiting its efficacy in many patients. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have emerged as pivotal regulators of gene exp
RNA structural switches are key regulators of gene expression in bacteria, but their characterization in Metazoa remains limited. Here, we present SwitchSeeker, a comprehensive computational and experimental approach for systematic identification of func
Fig. 1. Overview of the ROR family members. (A) Schematic representation of the domain structure of the three ROR family members (α, β, γ) and their isoforms. The isoforms are generated by alternative promoter usage and/or alternative splicing in the variable A/B domain. The other regio...
RNA-binding proteins potentially regulate alternative splicing of immune/inflammatory-associated genes during the progression of generalized pustular psoriasis Article 19 August 2024 Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states Article Open ...
Such variants, which lack the transmembrane domain as a result of alternative splicing, have been found in NSCLC patients that relapsed after anti-PD-L1 antibody treatment and are able to act as soluble decoys for anti-PD-L1 antibodies [149]. Tumour mutational burden and PD-L1 expression are...
An elemental amino acid-based milk formula (Neocate) served as the primary nutritional source from the age of twelve months. The shift from Neocate to an alternative elemental amino-acid-based milk formula resulted in a return to normal biochemical and radiological parameters, suggesting a possible...
Several alternative miRNA biogenesis pathways have also been described. Mirtrons, for example, bypass Drosha processing, being instead produced from spliced introns by the activity of the lariat debranching enzyme [10]. Another miRNA, pre-miR-451, is not processed by Dicer but rather by the ...
The transcription of lincRNAs can regulate gene neighbourhoods independently of the lincRNA transcripts themselves, suggesting the involvement of enhancer-like activity. lincRNA-derived small open reading frames are rapidly being described and can give rise to functional micropeptides, suggesting the nee...
Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have low long-term efficacy and are subject to therapeutic resistance. Deci