Loffler M. The biosynthetic pathway of pyrimidine (deoxy)nucle- otides: a sensor of oxygen tension necessary for maintaining cell proliferation. Exp Cell Res. 1989;182:673-680.Loffler M (1989) The biosynthetic pathway of pyrimidine (deoxy)nucleotides: a sensor of oxygen tension necessary for ...
by a newly discovered class of ATP binding cassette transporters, called Bacitracin efflux ABC transporters (BceAB), named after their first discovery in the bacitracin resistant strain ofBacillus subtilis14,15. InStreptococcus agalactiaesuch a BceAB-type ABC transporter is also present, as part of ...
Alleukaryoticcellscontainmostofthevariouskindsoforganelles,andeachorganelleperformsaspecializedfunctioninthecell.Organellesdescribedinthissectionincluderibosomes,theendoplasmicreticulum,theGolgicomplex,vacuoles,lysosomes,mitochondria,andtheplastidsofplantcells.所有的真核细胞都含有多 种细胞器,每种细胞器在细胞中推行一项...
Cochaperones of Hsp90 regulate hsp90 functions at many aspects. CDC37 (also called p50) delivers kinase to Hsp90 and inhibits its ATPase activity; Carboxyl terminus of Hsp70-interacting protein (CHIP) functions as E3 ubiquitin ligase; Hsc70/Hsp90-organizing protein (HOP, also called STI1) inh...
Moreover, notably, three “Replication and repair” downstream pathways (ko03030: DNA replication, ko03440: homologous recombination, ko03430: mismatch repair) were enriched in the rumen of BT cattle; two “Nucleotide metabolism” downstream pathways (ko00240: pyrimidine metabolism, ko00230: purine...
Mono-nucleotide repeats ≥ 10 nucleotides long were also masked. Sequence masking was done on the raw sequences (without gaps) while the locations of gaps were retained. Gaps were also masked as they arise by a non-point mutation process. The resulting masked alignments were then split into ...
Another powerful technique is Pyrosequencing, which enables high-resolution and sensitive monitoring of DNA methylation in real time by quantitatively measuring the incorporation of nucleotides [74], which makes it valuable for various research and clinical applications, including cancer prediction and repeti...
Thus, the decreased PRPP synthetase activity of the P5N-deficient erythrocyte is due, at least in part, to the ability of the accumulated pyrimidine nucleotides to sequester magnesium and to interfere with the subunit aggregation of PRPP synthetase. 展开 ...
dispersed repeats were masked before the identification of these polymorphisms. The orange curves depict the percentages of nucleotides that are part of repeats in the same windows, while the gray curves depict the percentages of nucleotides with guanine and cytosine bases. The locations of indels ≥...
Ribose plays a central role in the chemistry of modern life on Earth. The sugar backbones of ribonucleic acids (RNA) and deoxyribonucleic acids (DNA) are formed by polymeric chains of nucleotides which contain a ribose and a deoxyribose (a cyclic pentose without a 2′ oxygen), respectively. ...