This complex solution of polymers and colloidal particles is confined by the nuclear envelope that is comprised of a layer of intermediate filaments called lamins and two lipid bilayers (Alberts et al. 2014). Very recently, the nuclear envelope was found to be perpetually undulating (Chu et al....
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Nuclear pore complexes (NPCs) control biomolecular transport in and out of the nucleus. Disordered nucleoporins in the complex’s pore form a permeation barrier, preventing unassisted transport of large biomolecules. Here, we combine coarse-grained simul
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Lamins are the major components of the nuclear lamina, which regulate chromatin structure and gene expression. KAKU4 is a unique nuclear lamina component in the nuclear periphery, modulates nuclear shape and size in Arabidopsis. The knowledge about the r
How the subsequent steps of RDR are spatially segregated within the nuclear architecture is unknown. The nuclear periphery (NP) constitutes a boundary between the nucleus and cytoplasm and is formed of a double membrane nuclear envelope (NE) and multiple nuclear pore complexes (NPCs)11. NPCs are...
Co-labelling with the nuclear envelope protein lamin B1 revealed that at the time of maximal dsDNA break detection, a subset of nuclei exhibited envelope ruptures (discontinuation of lamin B1 labelling), resulting in perinuclear release of γH2AX in RNA-rich areas typical of the endoplasmic ...
The nuclear envelope that separates the contents of the nucleus from the cytoplasm provides a surface for chromatin attachment and organization of the cortical nucleoplasm. Proteins associated with it have been well characterized in many eukaryotes but n
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