Secondary active transporters of the SLC11/NRAMP family catalyse the uptake of iron and manganese into cells. These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. Here we describe the structural and functional properties of the prokaryotic...
A highly similar protein, Nramp2, is expressed ubiquitously and appears not to have a role in defense against infection. The Nramp proteins are members of a family of metal ion transporters, that includes the yeast Smf proteins.AM, LabrousseAM, Labrousse...
View PDF The NRAMP family of metal-ion transporters July 2006 Yaniv Nevo, Nathan Nelson View PDFView more articles Recommended articles Article Metrics Citations Citation Indexes451 Captures Readers363 Mentions Blog Mentions1 Social Media Shares, Likes & Comments2 View details ...
Once the host’s phagocytic cells engulf the pathogen, these cells use NRAMP1 (natural resistance-associated macrophage protein, encoded in humans by the SLC11A1 gene)—and possibly other metal transporters—to limit the availability of manganese to intracellular pathogens [22]. Characterized ...
Mutational analysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters. We have recently shown that a member of the Nramp family of metal transporters, Smf1p, is tightly regulated at the level of protein stability and protein s... FL Xiu,VC Culotta - 《...
The exact role of IRT1 in Mn, Zn and Co homeostasis has however not yet been investigated. Recent studies with rice and Arabidopsis have shown the importance of metal transporters of the NRAMP (NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN) family in Mn uptake in plants25,26. NRAMP1 is ...
Portnoy ME, Liu XF, Culotta VC: Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol. 2000, 20 (21): 7893-7902. 10.1128/MCB.20.21.7893-7902.2000. PubMed Central CAS PubMed Google Scholar Schaible UE, Kaufmann SH: ...
Molecular explanations for metal selectivity and the conformational change process in Nramp-family divalent metal transporters 来自 国家科技图书文献中心 喜欢 0 阅读量: 14 作者:Bane,Lukas,Weihofen,Wilhelm,Gaudet,Rachelle,Lee,Brandon,Bozzi,Aaron
Guerinot ML (2000) The ZIP family of metal transporters. Biochim Biophys Acta-Biomembr 1465:190–198. doi:10.1016/S0005-2736(00)00138-3 CASGoogle Scholar Guerinot ML, Yi Y (1994) Iron: nutritious, noxious, and not readily available. Plant Physiol 104:815–820 ...
The NRAMP family of metal-ion transporters 2006, Biochimica et Biophysica Acta - Molecular Cell Research Show abstract Lack of the bone morphogenetic protein BMP6 induces massive iron overload 2009, Nature Genetics Iron behaving badly: Inappropriate iron chelation as a major contributor to the aetiolo...