In the fast-developing digital era, improving young children’s learning abilities by information technology has become a goal of early childhood education. Accordingly, a novel digital puzzle gaming system for young children’s learning is proposed, which is based on interactive multi-sensing and ta...
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined ...
Camilo V, Pacheco MB, Moreira-Silva F, Outeiro-Pinho G, Gaspar VM, Mano JF, Marques CJ, Henrique R, Jerónimo C. Novel Insights on the Role of Epigenetics in Androgen Receptor’s Expression in Prostate Cancer.Biomolecules. 2023; 13(10):1526. https://doi.org/10.3390/biom13101526 ...
Waste Clearance in the Brain and Neuroinflammation: A Novel Perspective on Biomarker and Drug Target Discovery in Alzheimer’s Disease by Kazuhiko Uchida 1,2 1 Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Ibaraki, Japan 2 Institute for Biomedical Research, ...
Considering the complex pathogenesis of Alzheimer’s disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, one novel pyrrole-based hydrazide (vh0) and four correspondin...
The consumption of ‘not-from-concentrate’ (NFC) fruit juices can be a convenient and enjoyable way to incorporate the nutritional benefits and flavors of fruits into one’s diet. This study will focus on the effect of production of juices from apple an
Chang S, Torii S, Inamo J, Ishikawa K, Kochi Y, Shimizu S. Uncovering the Localization and Function of a Novel Read-Through Transcript ‘TOMM40-APOE’.Cells. 2024; 13(1):69. https://doi.org/10.3390/cells13010069 Chicago/Turabian Style ...
3.1. Overview of Genetic Findings in Sjögren’s Syndrome In recent decade, implementation of next generation sequencing, novel bioinformatic and biostatistic approaches enabled specific genetic analyses of race-dependent pSS-specific SNPs. Such genome-wide association studies (GWASs) have been conducted...
The novel score remains predictive of adverse survival outcomes. Abstract Background: The Peritoneal Carcinomatosis Index (PCI) and the Intra-operative Mapping for Ovarian Cancer (IMO), to a lesser extent, have been universally validated in advanced-stage epithelial ovarian cancer (EOC) to describe ...
Keywords: novel psychoactive drugs;substance misuse;psychosis;mental automatism;schizophrenia;cannabis;De Clerambault