We performed a systematic screening of 508 articles, from which we chose 115 relevant articles in a search for cell-in-cell events across the tree of life, the age of cell-in-cell-related genes, and whether cell-in-cell events are associated with normal multicellular development or cancer. ...
& Smith, A. Naive and primed pluripotent states. Cell Stem Cell 4, 487–492 (2009). Article CAS PubMed Google Scholar Ying, Q. L. et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519–523 (2008). Article CAS PubMed PubMed Central Google Scholar Ter ...
Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor microenvironment (TME). However, the function and mechanisms of tumor...
C, alterations in cell adhesion molecules in the transition between the normal epithelial cell state (left) and malignancy (right). The localization of the distinct cell adhesion complex types is shown. EGF, epidermal growth factor; CRP, complement regulatory protein domains. Cell adhesion molecules...
aoxidative damage to important molecules such as lipids, proteins, and DNA 对重要分子的氧化损伤例如油脂、蛋白质和脱氧核糖核酸 [translate] awhich may result in cellular dysfunction and mutations, thus losing the normal cell functions 哪些可以导致多孔的官能不良和变化,因而丢失法线细胞作用 [translate] ...
Somatic embryogenesis is a major process for plant regeneration. However, cell communication and the gene regulatory network responsible for cell reprogramming during somatic embryogenesis are still largely unclear. Recent advances in single-cell technol
The UHRF1-DNMT1 interaction is essential for the normal nuclear localization of DNMT1 and the maintenance of DNA methylation [19]. Studies have shown that the upregulation of UHRF1 expression or enhanced function promotes the epigenetic silencing of tumor suppressor genes (TSGs), thereby ...
This plasticity can operate in several manifestations (Fig. 2). Thus, nascent cancer cells originating from a normal cell that had advanced down a pathway approaching or assuming a fully differentiated state may reverse their course by dedifferentiating back to progenitor-like cell states. Conversely...
Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of nutrients while acting as a barrier for hostile luminal contents. Recent discoveries have revealed that the ...
Liu, Y., Beyer, A. & Aebersold, R. On the dependency of cellular protein levels on mRNA abundance. Cell 165, 535–550 (2016). CAS PubMed Google Scholar Fortelny, N., Overall, C. M., Pavlidis, P. & Freue, G. V. C. Can we predict protein from mRNA levels? Nature 547, E19...