The Nitric Oxide (NO) SolutionBill Gottlieb
NO: Nitric oxide Nrf2: Nuclear factor erythroid 2–related factor 2 PARP: Poly (ADP-ribose) polymerases PD: Parkinson's disease PGE2: Prostaglandin E2 PI3K: Phosphoinositide 3-kinase PNS: Peripheral nervous system ROS: Reactive oxygen species RPS6KA3: Ribosomal Protein S6 Kinase A3 ...
Nitric oxide (NO), hydrogen sulfide and polysulfides have been proposed to contribute to redox signaling by activating the Keap-1/Nrf2 stress response system. Nitrosopersulfide (SSNO−) recently emerged as a bioactive product of the chemical interaction of NO or nitrosothiols with sulfide; upon ...
Nitric oxide (NO) regulates production of vascular endothelial growth factor (VEGF) by normal and transformed cells. We demonstrate that NO donors may up-regulate the activity of the human VEGF promoter in normoxic human glioblastoma and hepatoma cells independent of a cyclic guanosine monophosphate–...
Nitric oxide (NO) is an endogenous bioactive factor and, as a signal molecule, can mediate the regulation of many pathways, including those associated with the circulatory system and cardiac protection101,102. In the treatment of MI, exogenous NO can stimulate the formation of blood vessels by ...
Zinc oxide nanoparticles MDA: Malondialdehyde TNF: Tumor necrosis factor INF: Interferon SILD: Sildenafil PDE5: Phosphodiesterase 5 NO/cGMP: Nitric oxide/cyclic guanosine monophosphate NF-kB: Nuclear factor kappa beta Nrf2/HO: Nuclear-related factor 2/Heme oxygenase NaOH: Sodium hydroxide...
During the initial phases of inflammation, M1 macrophages instigate inflammatory reactions through the generation of effector molecules, including ROS, nitric oxide, pro-inflammatory cytokines (interleukin (IL)-1β, tumor necrosis factor (TNF)-α), and chemokines. This, in turn, augments the ...
through the nitric oxide (NO) and hydrogen peroxide (H2O2) signaling pathways (Parwez et al.2023). Inhibition of ethylene production improves Ni toxicity tolerance by reducing ROS overaccumulation (Khan and Khan2014). JA (jasmonic acid) and SA (salicylic acid) both improve Ni toxicity tolerance...
Activated microglial cells produce various inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2, which may be neurotoxic (Graeber and Streit, 2010). Since excessive ...
CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95 Neuron, 20 (1998), pp. 115-124 View PDFView articleView in ScopusGoogle Scholar Jaffrey et al., 2002 S.R. Jaffrey, M. Fang, S.H. Snyder Nitrosopeptide mapping: a novel methodology ...