Brain metastasis (BrM) poses a significant challenge to the prognosis and quality of life for patients with non-small cell lung cancer (NSCLC). Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system (CNS), has been i
After surgery, the animals were immediately placed on a prewarmed pad until they became active, at which point they were returned to their home cages. Retrograde tracing Retrograde tracing was performed on SCID mice 3 months after transplantation. After administration of anesthesia, 0.1 μl ...
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA Cerise Tang, Vlad Makarov, Phillip Rappold, Kyle A. Blum & Renzo G. DiNatale Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA Ky...
Hertzman PA, Clauw DJ, Duffy J et al. (2001) Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia–myalgia syndrome. Arch Intern Med 161(19):2301–2306
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
(n = 67), respectively, while all 8 patients with tumor larger than 9 cm were symptomatic. Tumor diameter was obviously associated with the presence of clinical symptoms. In follow-up period, 7 patients in the conservative group (n = 39) received surgery because of tumor growth ...
Three weeks post-surgery, mCherry controls and ChR2 injected mice were assigned randomly to receive blue light stimulation (3 mW, 40 Hz, 1 min on/1 min off for 30 min) in either the black or white striped chamber. Day 1, mice were habituated to the entire apparatus for ...
Given the difficulty in obtaining samples from this young demographic, nearly all of the samples were collected from ADOL undergoing breast reduction surgery. While this may limit generalizability, mammoplasty is a very common source of tissue among breast cancer researchers. We had no information on...
Pancreatic cancer and adjacent noncancerous tissues were obtained from 68 patients who underwent surgical resection at the General Surgery Departments of the First and Second Hospitals of Lanzhou University. Quantitative real-time PCR (qRT-PCR) was performed on all the tissues, while immunohistochemical...
Duodenal catheter surgery Adult C57BL/6J wild-type mice were surgically implanted with catheters into the duodenum, using a similar procedure as previously described9,64. Mice were anesthetized with isoflurane (1–3% in oxygen). A 2-cm incision was made from the xiphoid process diagonally to th...