MAPT,PRNP,GRN) with clinical EOAD that are better known for their role in other neurodegenerative diseases. When interpreting the results of genetic studies of EOAD, it is important to ask several questions. First, is the phenotype in question clinically diagnosed EOAD or pathologically confirmed...
Recent research in neuroimmunology has revolutionized our understanding of the intricate interactions between the immune system and the central nervous system (CNS). The CNS, an “immune-privileged organ”, is now known to be intimately connected to the
astrocytes, pericytes, and nerve cells, is a complex obstacle for drug delivery in the treatment of nervous system diseases. This barrier was initially identified by Paul Ehrlich in 1885 [6]. BCECs are the main component of the BBB responsible for selective permeability to small ...
Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nat Rev Clin Oncol. 2016;13:228–41. Article CAS PubMed Google Scholar Chen H, Wang D, Zhong Q, Tao Y, Zhou Y, Shi Y. Pretreatment body mass index and clinical outcomes in cancer patients following ...
1. Compared to a GP group which does not receive peer delivered education, to examine whether training in and use of a dementia screening instrument and relevant information (see The Intervention section below) improves: i. GP identification (diagnosis) of dementia ii. Distinction by GPs between...
showed that Müller glia expressing α1T, a neuron-specific microtubule protein induced in the developing and regenerating CNS, can de-differentiate and become multipotent in the injured zebrafish retina [92]. Shortly after, Bernardos et al. (2007) found that Müller glia also express the ...
Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents. Eur. J. Neurosci. 2009, 30, 397–414. [Google Scholar] [CrossRef] Logue, S.F.; Grauer, S.M.; Paulsen, J.; Graf, R.; Taylor, N.; Sung, M.A...
However, it is increasingly recognized that ALS is a multisystem disorder in which other non-motor (and in particular, cognitive and behavioral) impairments can be observed [13,14], whereas, on the other side, FTD can be associated to signs of motor neuron disease (FTD-MND) [15]. ...
(GP) Ib or the GPIIb (IIb) promoter can lead to the storage of FVIII in platelet -granules and that platelet-derived FVIII can improve hemostasis in hemophilia A mice actually in the presence of anti-FVIII inhibitory antibodies (referred to as inhibitors) (13, 15, 17, 21). In addition ...
All patients were enrolled under a hospital clinical research protocol from the tertiary Memory Clinic (CM2R) of Alsace, France, by an experienced team of clinicians. A total of 166 patients were included in this study: 21 control subjects (CS), 51 patients with DLB at the prodromal stage ...