The magnitude of these adverse outcomes will be more pronounced as disease severity, strain virulence, or host vulnerability increase. It is the cost of these treatment delays and failures to patients and the h
Finally, we identify strong negative epistasis between two unrelated resistance mechanisms: thetetracycline resistance gene and loss-of-functionmutations involved in aminoglycoside tolerance. Our study highlights important constraints that may allow better prediction and control of antibiotic resistance evolution...
Antibiotics, especially broad-spectrum antibiotics, may generally have a negative impact on the diversity of the gut microbiome and promote the expansion of antibiotic-specific ARG in humans. For example, Willmann et al. found a significant difference in the effect of ciprofloxacin and cotrimoxazole...
Here, we consider the negative impact of the toxic contaminants arising from these fires on the immune system, with a focus on how wildfire pollution can exacerbate inflammatory diseases. Cezmi A. Akdis Kari C. Nadeau Comment30 Aug 2022 Nature Reviews Immunology Relevance of international ...
Infection (2024) 52:83–91 https://doi.org/10.1007/s15010-023-02056-1 RESEARCH The impact of antibiotic stewardship interventions and patient related factors on antibiotic prescribing in a vascular surgical department M. M. Gruber1,2 · A. Weber1,2 · J. Jung1,3...
Macrodantin,nitrofurantoin- derivative of nitrofuran used as an antibacterial medicine (trade name Macrodantin) effective against a broad range of Gram-positive and Gram-negative bacteria; used to treat infections of the urinary tract Rifadin,rifampin,Rimactane- an antibacterial drug (trade names Rif...
Importantly, in this study, neither exposed nor the control children were antibiotic-treated after birth. Therefore, the administration of antibiotics during this critical developmental window can lead to short- and intermediate-term negative effects on the microbiome and resistome. Table 2 Key ...
The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. Among resistant pathogens, methicillin-resistant Staphylococcus aureus (MRSA) poses a particularly severe and expanding threat. Howe
of predominantly negative effects in panelashows that STAT mice cohoused with Control mice more often weighed less than their comparison group (i.e. STAT mice living with other STAT mice); similarly, the asymmetric distribution of effects in panelbshows that Control mice in cages cohoused with ...
Its impact on societies worldwide is immense, resulting in loss of human life and money. An alarming pattern of resistance involving multidrug-resistant and sometimes pandrug-resistant Gram-negative bacteria is currently emerging. In response to the global public health threat posed by antimicrobial ...