Immunology The multifaceted role of neutrophils in HIV-1-infection THE UNIVERSITY OF ALABAMA AT BIRMINGHAM Zdenek Hel BowersNathan LIn recent years, a new appreciation of the role of neutrophils in regulating the immune system has emerged. Neutrophils are the most abundant leukocyte population and ...
11,18it is quite surprising that neutrophils have been largely overlooked in the context of alloHSCT. Herein, we review the most relevant studies centered on the features, functions and roles played by human neutrophils in alloHSCT, in both the donor [during peripheral...
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Neutrophils are myeloid cells that constitute 50–70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrop...
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The diverse biological functions of neutrophils, beyond the defense against infections. Inflammation. 2017;40:311–23. Article CAS PubMed Google Scholar Wang X, Qiu L, Li Z, Wang XY, Yi H. Understanding the multifaceted role of neutrophils in cancer and autoimmune diseases. Front Immunol. ...
In the tumor microenvironment, neutrophils have varied functions and have been classified using different terms, including N1/N2 neutrophils, tumor-associated neutrophils, and polymorphonuclear neutrophil myeloid–derived suppressor cells (PMN-MDSCs). These populations of neutrophils are primarily defined by...
FXII deficiency is linked to decreased infiltration of inflammatory cells into skin windows [6]. FXII facilitates the recruitment of neutrophils, binds to the surface of pathogens (bacteria, fungi, viruses, and neutrophil extracellular traps (NETs) where it autoactivates [7]. FXII promotes ...
The multifaceted functions of the SASP Full size image Various internal and external stimuli lead to cell senescence. The SASP as a characteristic of senescent cells plays various roles through autocrine or paracrine. The SASP can recruit immune cells to eliminate senescent cell, but it also can ...
Here, we have highlighted the multifaceted functions that NETs play in the pathogenesis of COVID-19. The role of NETs in COVID-19 is increasingly supported by multiple lines of evidence and in fact, explains the wide range of manifestations seen in the most severe and critical cases. In the...