Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation
Therefore, SARs that apply to one subclass of prenylated (iso)flavonoids might not apply to another. Methylation is one of the most common decorations of prenylated (iso)flavonoids. Methylation at the C7, for example, slightly reduces the anti-MRSA activity of prenylated isoflavones13,14, has ...
rectal administration and injectable administration (Table1). Oral administration is the most commonly utilized and safest method of drug delivery, offering unparalleled convenience and cost-effectiveness [19]. However, oral administration is hindered by the physicochemical properties of the drug itself, a...
Epigenetic modifications have long been recognized as an essential level in transcriptional regulation linking behavior and environmental conditions or stimuli with biological processes and disease development. Among them, methylation is the most abundant of these reversible epigenetic marks, predominantly occurr...
Cattle were deprived of water during transportation, while they could eat some wheat straw, which was placed on the sides of the cart in the form of straw bundles when loading. Before transport, the ratio of concentrate and wheat straw in diet was 30:70. The concentrate was purchased from ...
Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. However, chemotherapy resistance typically develops after an initial p
By using an IEM, the cation head group is immobilized in the polymer matrix to minimize CO2exposure and avoid the formation of carbonate precipitates in the AEMFC/AEMWE [2,24,38]. While no carbonate precipitates may form, AEMFC/AEMWE are sensitive to CO2as CO2ingress leads to a carbonatio...
The phosphorylation status was calculated as the ratio of phosphorylated protein/total protein. The antibody list is reported in Supplemental Table S2 (https://doi.org/10.3168/jds.2017-13707). The GAPDH was used to normalize target protein abundance. Promoter Region-Specific DNA Methylation The DNA...
DNA methylation is among the most common forms of DNA modification in prokaryotic and eukaryotic genomes. DNA methylation has various effects on fundamental biological processes, including the silencing of transposable elements (TEs) and the regulation of chromatin structure, gene expression, genetic recom...
A taxonomic classification that accurately captures evolutionary history is essential for conservation. Genomics provides powerful tools for delimiting species and understanding their evolutionary relationships. This allows for a more accurate and detail