However, these loading rates are not representative of those seen in trauma, and there is currently no knowledge of the underlying mechanisms at the micro- and nanoscale. Collagen type I is the most abundant structural protein in ligaments, where it determines deformation and failure mechanisms4. ...
Piezo1 is detected in osteoblasts (which are the most abundant bone cells), and Piezo1-Akt channels are key players in tissue remodeling, wherein they mainly act on osteoblasts. Among these signaling effects, Piezo1-Akt signaling and the inhibition of sclerostin (which is an important regulator...
Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infecti
Albumin and fibrinogen are the most abundant proteins in human blood [56,57,59,60]. Apart from mentioned proteins, human plasma contains also immunoglobulins and adhesive proteins which are essential for high viability, strong adhesion as well as proliferation of anchorage-dependent cells [51,56,...
Collagen is more than a profile and that's what we here offer you with VEGCOL™ This is neither an 'amino acid blend', nor a 'builder' Vital Collagen in the Body Collagen is a fundamental component of the human body as the most abundant protein. Its presence is ubiquitous across ...
The overlap is particularly evident for the most abundant core matrisome proteins belonging to the collagen and proteoglycan categories (Fig. 4A, right panel). Therefore, to define the extracellular matrix composition of a tissue, we combined the data from two independent samples including only those...
During fetal development, immediately following the initiation of bone collar formation, bone marrow and trabecular bone occupy the center of the cartilage template and create a highly vascularized environment that is considered to host abundant MPs (Fig. 2). The metaphyseal marrow cavity and ...
covers the articular cartilage. Since the blood supply from the epiphyseal arteries has no direct access to the medullary region, they tend to enter via extensive networks in the peri-articular vascular plexus. This plexus helps maintain isolated blood circulation, which is essential for skeletal ...
After successful surgeries for patients with rhegmatogenous retinal detachment, the most common cause of retinal redetachment is proliferative vitreoretinopathy (PVR), which causes severe vision impairment and even blindness worldwide. Until now, the major treatment for PVR is surgical removal of the...
The change in the amount of cancellous bone depends not only on the distance from the joint surface, but also on the distance from the cartilage growth zone. The implantation was a standardized operation. When we implanted the prosthesis, the stem passed through the growth plate. The distal ...