Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a direction in treating diseases and an essential strate...
The insert shows the integrated intensity of the peaks as function of aggregation time, corresponding to depletion of monomers and possibly of small, mobile oligomers. Full size image To discriminate between these possibilities, we performed negative stain TEM. As shown in Fig. 3D, hIAPP forms ...
Lane 3, boiling of the oligomerized sample with SDS results in dissociation of the heptamers into monomers. The 129YTRF Mutation Exerts a Dominant Negative Effect upon Membrane Insertion of Wild Type Toxin into Fibroblast Membranes To learn more about the functional properties of the129YTRF ...
Two distinct protein domains are present in IDOL: an N-terminal FERM (band 4.1/ezrin/radixin/moesin) and a C-terminal RING domain (12, 14). In contrast to secreted PCSK9, which interacts with the LDLR extracellularly, IDOL is a 45-kDa cytoplasmic protein that interacts with the intracellu...
The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability. They have been implicated
Ascorbic acid (ASC), a small molecule antioxidant, is commonly found in plant tissues. Antioxidative functions of that compound are implemented in Halliwel... D Gierszewska,J Tyburski,A Tretyn - arXiv 被引量: 0发表: 2010年 From Actin Monomers to Bundles: The Roles of Twinfilin and α-Ac...
A Tris molecule is positioned at this axis buried in the protein. Ligands are depicted as stick models. B) An overlay of monomers of the MCLC structures in the closed form (orange) and open form (grey). The C-terminal lid domain is rotated about 30° resulting in a shift of ...
This enzyme was purified to homogeneity from the culture medium, and its sequence was determined using both direct protein sequencing and DNA sequencing of a genomic clone containing the hexA gene [16]. In the present work, to initiate structural studies of this enzyme we performed sequence ...
et al. Critical role of interfaces and agitation on the nucleation of Aβ amyloid fibrils at low concentrations of Aβ monomers. Biochim. Biophys. Acta Proteins Proteom. 1804, 986–995 (2010). Article CAS Google Scholar Gray, J. J. The interaction of proteins with solid surfaces. Curr....
(ED) pathway1,2. As monomers, glucose, and its derivatives are also involved in the synthesis of various macromolecules and cellular components3,4. Moreover, glucose also serves as an important feedstock in the biorefinery industry, supporting the cultivation of multiple microbial cell factories ...