A monomer is defined as a small molecular unit that can be linked to other units to form a repetitive chain. The repetitive chain is called a polymer, and some examples of biologically relevant polymers include DNA, carbohydrates, and proteins....
Proteins:Along with carbohydrates, lipids, and nucleic acids, proteins are one of the major biological macromolecules. Proteins are found in all living cells, and they are essential for the cells' survival as they carry out a vast amount of cellular functions....
The monomer unit of proteins is alpha-amino acids. Two examples and their zwitterionic forms are :
The second key challenge is the selection of an appropriate representation for the input. Many different encoding schemes for proteins have been described in the literature, including most recently ones adopting language models; some of these are antibody-specific and some are general to protein seque...
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that starts
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The two viral proteases of coronavirus are excised from the polyproteins through autocleavage and work together to cleave the polyproteins, leading to 16 functional non-structural proteins (Nsps). The 3CLpro of SARS-CoV-2 specifically cleaves at 11 positions on the large polyprotein 1 ab (...
polymerization of styrene and acid monomer (Fig 1). The core is surrounded by a layer of magnetite, which gives the bead its superparamagnetic properties. The magnetite is locked in by polymer encapsulation. The surface of the bead is modified to minimize non-specific binding of proteins ...
These helices may or may not be the native ones depending on the importance of the local signals. A more detailed discussion of local signals in funnel geometries is given by Saven and Wolynes[25]. For our discussion here, as long as the appropriate reduction of entropy per monomer unit ...
EC-SOD can be separated into monomer and dimer by reverse-phase HPLC [23]. The isolated dimer was subsequently denatured and alkylated using iodoacetamide. The alkylated material was subjected to reverse-phase HPLC using a C8 column. The material separated into three major peaks without base-line...