Nevertheless, other symptoms have been accurately modelled, and these, together with clinical data, are providing insight into the neurobiology of depression. Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive ...
SSRI 原理 基于decreased monoamine function → depression(浅显, 因为depletion of monoamines produce a mild reduction in mood in unmedicated depressed patients, but such manipulations do not alter mood in healthy controls)(感觉生物里总有些这样非常复杂) increase monoaminetransmissionacutely14 , either by ...
Further studies of the dynamic role of microglia in the neurobiology of depression and synapse function may reveal novel molecular pathways that can be therapeutically targeted. Abstract Data from clinical and preclinical studies indicate that immune dysregulation, specifically of inflammatory processes, is...
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2. Correlation between anxiety/depression and neurogenesis in the rodent: dual action of fluoxetine and effects of running 3. Correlation between depression and neurogenesis in humans 4. Effects of fluoxetine and exercise on the proliferation of adult dentate gyrus and SVZ cells 5. Cognitive effects...
Twitter Google Share on Facebook Medical Encyclopedia Wikipedia neu·ro·phar·ma·col·o·gy (no͝or′ō-fär′mə-kŏl′ə-jē, nyo͝or′-) n. The study of the action of drugs on the nervous system. neu′ro·phar′ma·co·log′i·cal(-kə-lŏj′ĭ-kəl)adj. ...
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review,
Krishnan, V. & Nestler, E. J. The molecular neurobiology of depression.Nature455, 894–902 (2008). ArticleCASPubMedPubMed CentralGoogle Scholar Drysdale A. T., Grosenick L., Downar J. Resting-state connectivity biomarkers define neurophysiological subtypes of depression.23, 28–38 (2017). ...
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