Ku70, a protein that binds to the ends of DNA double-strand breaks and initiates nonhomologous end-joining, is deacetylated by SIRT1.45 In a model system of radiation-induced DNA damage (luciferase reporter gene), SIRT1 expression enhanced annealing of DNA breaks in vitro; this was not ...
:chains: A Framework for Building High Value Public Blockchains :sparkles: - cosmos-sdk/tools/cosmovisor/go.sum at 9569b3499747732a08c7103e14f09af2119d3d50 · the-denom/cosmos-sdk
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In the last decades the survival of metastatic gastrointestinal (GI) cancer patients could have been significantly extended due to the introduction of targ
It contains a DNA-binding domain and two RNA-binding domains that bind VL30-1 RNA in mice, which leads to the release of PSF from a repressed proto-oncogene and activates transcription of the latter ones.72-74 However, VL30-1 RNA is not encoded in the human genome and Li et al. ...
not all HIV infected cells are rapidly eliminated. The proportion of all lymphocytes that are infected is relatively low (1:100–1:1000). As such, the progressive loss of CD4 cells that is characteristic of untreated HIV infection is not due to direct viral killing per se, but to associated...
[69]. The result is the model IRS tyrosine phosphorylation timecourse of Figure2C: initially it rises, within the first minute of insulin stimulation; then as PKC becomes active (after about 5 minutes) and produces serine phosphorylated forms of IRS, which do not signal downstream, IRS_TypP...
Even though the pandemic is still not under control in several parts of the world, its varied impacts on the global economy are already evident. In the electricity sector, the confinement measures have caused unseen impacts in history, mainly due to the pronounced and prolonged reduction in ...
Late blight, caused by Phytophthora infestans, is a major potato disease globally, leading to significant economic losses of $6.7 billion. To address this issue, we evaluated the antifungal activity of ZnO and CuO nanoparticles (NPs) against P. infestans for the first time in laboratory and gree...
Under the dyeing conditions in this study, the size distributions of Ad(y)-SAP microparticles were almost the same before and after dyeing (data not shown). It is thus likely that pararosaniline has no effect on the properties of Ad(y)-SAP microparticles and on the interaction of βCD(...