microRNAs (miRNAs) have a pivotal role during the formation and function of the cardiovascular system. More than 300 miRNAs have been currently found within the mammalian genome, however only few specific miRNAs, named endomiRNAs, showed conseved endothelial cell expression and function. In this ...
This article demonstrates that exosomes contain mRNAs and miRNAs and mediate their transfer between cells. CAS PubMed Google Scholar Nolte-'t Hoen, E. N. et al. Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with ...
Additionally, circRNAs are evolutionarily conserved, relatively stable, and can bind certain microRNAs (miRNAs) or RNA-binding proteins (RBPs), thus regulating gene expression at the posttranscriptional level14,15,16. Recently, deregulated expression of certain circRNAs has been identified in many ...
Thus, the activation state and modulation of cytokines, chemokines, ROS, miRNAs, and eRNAs in macrophages are directly or indirectly targeted by circadian components. The global or T cell-specific deficiency in BMAL1 does not markedly impact the overall or subset-specific oscillation of T cells [...
(DNA Methyltransferase 3 beta), which in turn regulates MMP9 (Matrix metallopeptidase 9) levels. Because MMP alters junctional proteins (e.g., occludens, claudins, and cadherins), this leads to an impact on BBB permeability [9]. In fact, miRNAs (miR-150, miR-212, miR-132, miR-501-...
Given the documented role of PMPs in both disease states [29,30], coupled with the abundance of PMPs within the circulation [2] and their propensity to transfer miRNAs [19,21], we hypothesised that PMP-induced angiogenesis is driven by miRNA regulation of endothelial cell function. In the ...
Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer[J]. Cancer Cell Int, 2020, 20(1): 560. doi: 10.1186/s12935-020-01660-7. https://www.ncbi.nlm.nih.gov/pubmed/33292283 Cited in this article [2] Abstract...
, proteomic, metabolic bio-molecules that are increasingly being recognized as biomarkers comprise mutated DNA/matrix RNA expression, altered/methylated DNA, altered protein levels, qualitative and quantitative alterations in low molecular mass metabolites [258,259,260,261,262,263]. Exosomal miRNAs and ...
RNAi has become a standard experimental tool and its therapeutic potential is being aggressively harnessed. Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery. In particular, it has highlighted the assembly and ...
(miRNAs). Small single-stranded RNA molecules that function in the post-transcriptional regulation of gene expression. Demethylase An enzyme that induces demethylation: that is, the removal of a methyl group from a molecule. Deacetylase An enzyme that induces deacetylation: that is, the removal of...