The systematic use of mice of both sexes to model mood disorders has been poorly addressed, although sex differences get more attention than in the past (for review see [185]). For instance, a large proportion of experiments have been carried out on male mice when two-thirds of patients ar...
An intervention could mimic a targeting of age-dependent change by affecting ASPs directly (i.e., independently of age-dependent change in these phenotypes). For instance, a specific genetic variant may increase the number of neurons by promoting neurogenesis during brain development, without affectin...
Even in this case, the t-butyl group was retained to avoid interferences in the binding and to mimic the ester connection with a payload. In order to verify if elongation of the linker could turn into a lower interfer- ence in integrin-ligand binding, we planned to synthesize more complex...
Finally, we used an FGF19 and PPARα agonist on primary hepatocytes to mimic the combined effects of the gut-liver axis on CYP7A1. The results showed that CYP7A1 was suppressed when cocultured with the PPARα agonist and low-dose FGF19 (Figures 6I and S7H). Download: Download high-...
This study focuses on the role of humour in health and well-being of women-who-have-sex-with-women (WSW) during COVID-19. This group has been shown to be v
Another cardiac organoid model termed “Cardioid” contained a large internal chamber surrounded by CMs, ECs, and epicardial cells [22]. These approaches yield multi-cellular and structural cardiac organoids, but they can only mimic a certain degree of the physiological and metabolic functions of ...
Thus, it is not critical to mimic precisely the peptide backbone or the peptide’s side-chain orientation. One of the puzzling aspects of MDM2 inhibitor design has been the role of the fourth substituent. Modifications to this group alter the compounds’ physicochemical characteristics and have a...
DJ techniques require very niche skills with vinyl turntables, and of course digital technologies have been developed to simplify and mimic these. Native Instruments (NI) Traktor software was launched in 2000 and became recognized as the first digital DJ sync-tool, assisting beat matching and ...
Sinus involvement can mimic disease caused by mucormycosis, with facial and peri-ocular pain as well as fever and nasal congestion. Severe invasive sinus disease can result in CNS involvement, with venous sinus thrombosis. The lack of specificity of these symptoms is compounded in the ICU setting...
Interestingly, also in a completely different animal model—song learning in zebra finches—it was shown that new spines are generated in the forebrain nucleus HVC when an animal learns a new song from a tutor [32]. Finally, what about the experiment that has long been on the agenda [33]...