MicroRNAs are ubiquitous in all the body fluid types tested. Fluid type-specific miRNAs may have functional roles associated with the surrounding tissues. In addition, the changes in miRNA spectra observed in the urine samples from patients with different urothelial conditions demonstrates the potential...
A single microRNA (miRNA) can target and regulate hundreds or thousands of mRNAs; aberrant miRNA expression is involved in the initiation of many diseases, including cancer MiRNAs are potentially useful as biomarkers in cancer diagnosis, prognosis and response to treatment owing to the unique express...
Mycosis fungoides (MF) is the most common type of cutaneous T cell lymphoma. As the early clinical manifestations of MF are non-specific (e.g., erythema or plaques), it is often misdiagnosed as inflammatory skin conditions (e.g., atopic dermatitis, psori
In addition, small RNAs in EVs can be identified by using CNF sheet capture for small RNA profile analysis. Through CNF sheet analysis in the body, this method unveils the unique profile of ascites EVs in the very early phases of cancer progression in vivo and the actual location-based ...
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MicroRNA (miRNA) has gained the most interest due to its stability, moreover in most human cancers the miRNA levels are altered, and its expression is tissue specific. MicroRNA can be detected not only in tissue samples but also in serum and urine, as well as other accessible sources ...
Mass spectrum myoFBs: Myofibroblasts NO: Nitric oxide PSCs: Pluripotent stem cells scRNA-seq: Single-cell RNA sequencing SMCs: Smooth muscle cells snRNA-seq: Single-nucleus RNA sequencing ST: Spatial transcriptomics TGF-β: Transforming growth factor ...
Tumor-derived exosomes (TDEs), also called “oncosomes,” carry a specific cargo composed of an array of defined lipids, mRNA, microRNA, and biologically active proteins (6). Recent high throughput proteomic studies of exosomes isolated from various cells types and bodily fluids have catalogued ...
Here we dissected the relative contributions of the components of male reproductive system (MRS) during early male-to-female ZIKV transmission by utilizing mice with altered antiviral responses, in which ZIKV is provided an equal opportunity to be seeded in the MRS tissues. Using microRNA-targeted...
C. et al. Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology 87, 2198–2205 (2016). Article CAS PubMed PubMed Central Google Scholar Gilles, M. E. & Slack, F. J. Let-7 microRNA as a potential therapeutic target with implications for ...