OBJECTIVES: Lipocortin-1 (LC-1), a member of annexin family of calcium-binding proteins induced by corticosteroid, originally evoked interest as one of the secondary messengers in the antiinflammatory action of corticosteroid, But the ex... SW Choi,B Yoo,MJ Kim,... 被引量: 6发表: 1997年...
As PI lipids form the scaffold for PI3K signaling at the plasma membrane, it is possible that specific onco- genic alterations may act via regulating the production of the second messengers that control cancer cell growth and survival. In prostate cancer, knockdown of ELOVL7 reduced saturated ...
MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J. Immunol. 187, 2595–2601 (2011). Article CAS PubMed Google Scholar Krasteva, P. V. & Sondermann, H...
Hangzhou 310003, China Key words human urine extract; cell differentiation agent 2(CDA-2); apoptosis; myelodysplastic syndrome; phosphoinositide 3-kinase/Akt; xenograft 1This work was partly supported by the Chinese National Foundation for the Development of High Technology (863 program; No 2006AA02...
Also, both lipids act as second messengers that play important roles in many signaling pathways. DAG is able to induce structural changes in membrane, more efficiently than ceramide, requiring as little as 2 mol% [180]. This difference in efficiency is likely due to the different physical ...
Among these, c-di-GMP, c-di-AMP, and 3′3′-cGAMP are synthesized by bacteria and identified as secondary messengers that mediate STING signal transduction in prokaryotic cells, while 2′3′-cGAMP functions as the initiator of STING in mammalian cells [103]. The anti- tumor potential of ...
Our results suggest that ceramide could be involved in early stages of the exocytosis and after that, when calcium increase steadily, activities of ceramidase hydrolyzes ceramide leading to the generation of new second messengers. Exogenous ceramide can activate n-SMase in vivo, which hydrolyzes SM...
Thus, future research may help provide insight on the chemical messengers required to induce complex activation, the mechanisms of signalling to the nucleus, the genes regulated via pheromone module signalling and the biological consequences of this pathway. By characterising this pathway as a critical...
are derived from the same precursor, phosphatidate [206]. As PI lipids form the scaffold for PI3K signaling at the plasma membrane, it is possible that specific oncogenic alterations may act via regulating the production of the second messengers that control cancer cell growth and survival. In pr...
In the brain, MAO-B plays an important role in the breakdown of neurotransmitters (chemical messengers) like DA. MAO inhibitors (MAOI) such as selegiline, rasagiline etc. block the action of the enzyme MAO B161. Rasagiline is about 10 times more potent in the inhibition of MAO-B than ...