We propose that a very similar mechanism operates when vancomycin binds to the free D-alanyl-D-alanine termini in the cell wall, except in this case the steric hindrance blocks another set of enzyme...Reynolds, P. 1961. Studies on the mode of action of vancomycin. Biochim. Biophys. Acta ...
n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identifi...
The Properties of Linezolid, Rifampicin, and Vancomycin, as Well as the Mechanism of Action of Pentamidine, Determine Their Synergy against Gram-Negative B... Combining pentamidine with Gram-positive-targeting antibiotics has been proven to be a promising strategy for treating infections from Gram-...
Covalently linked vancomycin dimers have attracted a great deal of attention among researchers because of their enhanced antibacterial activity against vancomycin-resistant strains. However, the lack of a clear insight into the mechanisms of action of these dimers hampers rational optimization of their ant...
Jung WK, Koo HC, Kim KW, Shin S, Kim SH, Park YH (2008) Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Environ Microbiol 74:2171–2178 Article CAS Google Scholar Shahbazi N, Zare-Dorabei R (2019) A facile colorimetric and...
underlines the complex genetic mechanisms that occur in the transition of vancomycin-susceptible MRSA to hVISA and VISA [9]. One mechanism of reduced susceptibility in VISA strains is a thickened cell wall. This is the end result of a process that is achieved either by producing excess cell ...
For many other diseases, however, this link is poorly understood, in some cases because the mechanism of action of the drug has not been fully elucidated, or in other cases because a true pharmacodynamic endpoint may be unavailable. Overcoming these problems is critical if the clinician is to ...
In concert with improvements in personal hygiene and public sanitation, the discovery and development of antibiotics during the latter half of the last century has reduced substantially the morbidity and mortality associated with bacterial diseases. However, the past decade has witnessed a sharp reduction...
Voth DE, Ballard JD (2005) Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 18(2):247–263. https://doi.org/10.1128/CMR.18.2.247-263.2005 Article CAS PubMed PubMed Central Google Scholar Wahid R, Kotloff KL, Levine MM, Sztein MB (2019) Cell...
The continued emergence of multi-drug-resistant bacteria is a major public health concern. The identification and development of new antibiotics, especially those with new modes of action, is imperative to help treat these infections. This review lists t