Munoz-Alonso MJ, Gonzalez-Santiago L, Martinez T, Losada A, Galmarini CM, Munoz A (2009) The mechanism of action of plitidepsin. Curr Opin Investig Drugs 10: 536-542.Munoz-Alonso, M. J. et al. The mechanism of action of plitidepsin. Curr Opin Investig Drugs 10, 536-542 (2009)...
DISCUSSION Preclinical evaluation Although the mechanism of action of plitidepsin remains to be fully characterised, several targets have been identified in various cellular models.15 Plitidepsin caused a dose-related arrest of cell cycle and cell apoptosis following the induction of an early ...
SARS-CoV-2 viral proteins interact with the eukaryotic translation machinery and inhibitors of translation have potent antiviral effects. Here we report that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (IC90 = 0.88 nM) 27.5-fold more potent tha...
et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int. J. Pharm. 365, 121–130 (2009). Article CAS PubMed Google Scholar Kubo, T. et al. CpG-DNA enhances the tight junction integrity of the bronchial epithelial cell barrier....
The mechanism of action of the therapeutic agents has also been mentioned in Table 1. Anti-viral agents have specific intervention points in crucial stages like viral entry, viral replication, translation of viral proteins, assembling of new virions and viral budding, etc. thereby they can ...
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Investigational antivirals and their mechanism of action during the viral life cycle Virology SARS-CoV-2 is an enveloped, positive-sense, single-stranded ribonucleic acid (RNA) virus belonging to the familyCoronaviridae, subfamilyOrthocoronavirinae, and genusBetacoronavirus[126]. Open reading frames ...
Marine organisms contain valuable chemical compounds as secondary metabolites such as bioactive peptides that survive in harsh marine environments produced by organisms. They have been considered by scientists for use in medicine and pharmaceutical resea
Ma et al.explored the mechanism of previously reported Mproinhibitors. Specifically,31(ebselen),32(disulfiram),33(tideglusib),34(carmofur),35(shikonin), and36(PX-12) were investigated mechanistically employing native mass spectrometry, molecular dynamics simulations, FRET-based enzymatic assay, cellula...
McDonald LA, Eldredge GS, Barrows LR, Ireland CM (1994) Inhibition of Topoisomerase II catalytic activity by pyridoacridine alkaloids from aCystodytessp. ascidian: a mechanism for the apparent intercalator-induced inhibition of Topoisomerase II. J Med Chem 37:3819–3827 ...