Isoniazid (INH) and ethambutol (EMB) are two major first-line drugs for managing tuberculosis (TB), caused by the microbe Mycobacterium tuberculosis . Although co-use of these two drugs is common in clinical practice, the mechanism for the potential synergistic interplay between them remains ...
Define ethambutol. ethambutol synonyms, ethambutol pronunciation, ethambutol translation, English dictionary definition of ethambutol. n. An antibacterial drug, C10H24N2O2, used in a hydrochloride form with other drugs to treat pulmonary tuberculosis. Am
Insights into the spectrum of activity and mechanism of action of MGB-BP-3. ACS Infect Dis. 2022;8:2552–63. https://doi.org/10.1021/acsinfecdis.2c00445. 112. Kerr L, Browning DF, Lemonidis K, Salih T, Hunter IS, Suck- ling CJ, et al. Novel antibiotic mode of action by ...
Hepatitis is a common adverse effect of antituberculosis drugs. Silymarin prevented drug-induced hepatoxicity in animals with anti-oxidative mechanisms but its effect in human has been unknown. We aimed to evaluate the efficacy of silymarin for preventin
Their mechanism of action may also be effective against other pathogens. Thus, these drugs can also be used in the treatment of other diseases. This is known as drug repurposing and it is gaining attention due to the significant rise in the costs of pharmaceutical R&D. The pharmaceutical ...
Their mechanism of action is thought to result from inhibition of the nuclear translocation of the transcription factor NFAT (nuclear factor of activated T-cells) thereby preventing downstream initiation of transcription of T-cell cytokines. 5.4.8.2. Efficacy and selection A single trial has ...
In the nineteenth century the advancement of science was largely due to an organized, descriptive effort associated with a number of important discoveries. It rested on a freeing of the intellect in a way that permitted scientific empiricism; it was aide
J. Mechanism of action of and mechanism of reduced susceptibility to the novel anti-clostridium difficile compound LFF571. Antimicrob. Agents Chemother. 56, 4463–4465 (2012). Article CAS PubMed PubMed Central Google Scholar Galderma and NovaBay Enroll First Patients in Phase 2b Clinical Study ...
Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–29. Article CAS PubMed PubMed Central Google Scholar Dusso AS, Brown AJ, Slatopolsky E, Vitamin D. Am J Physiology-Renal Physiol. 2005;289. Liu PT, Stenger S, Li H, Wenzel...
The mechanism of immune destruction is complex and involves both direct HIV-mediated cytopathic effects (such as destruction of indi- vidual cells and formation of syncytia) and indirect, nonvirologic mechanisms (reviewed in detail in [1 OJ). The latter include the action of HIV as a super...